Table 1—

Descriptive information for the 11 trials

First author [ref no.]Subjects nF:MAge mean±sd (range)Duration of asthma yrs mean (range)BlindnessDuration of treatment daysExcluded patients nMedicationOutcome measures reported
Chow 251611 (8–13)SB210YesFEV1
Christensen 21711:632.2 (19–48)DB350Not clearPEFR
Dias 6209:1141.6±15 (18–73)DB21.70YesPEFR
Fung 2619(9–13.5)SB0YesFEV1/FVC/PEFR
Luu 271711:631±11 (19–61)16 (2–51)DB110Not clearVC/PEFR
Mitchell 13113:1829 (15–55)23 (5–38)SB295YesPEFR
Morton 281313:0(17–27)DB350YesFEV1
Tandon 24156:940.5 (19–57)(5–34)DB350YesPEFR/FEV1/FVC/
Tandon 29166:1039.1±16 (11–60)19.62 (2–49)DB30YesFEV1
Tashkin 301210:243±11 (16–64)21.83 (1–45)DB30YesFVC/FEV1/FEF
Tashkin 232616:1034±18.59 (8–73)21.28 (2–59)DB281YesFVC/FEV1
  • M: male

  • F: female

  • SB: single-blind

  • DB: double blind

  • FEV1: forced expiratory volume in one second

  • FEF: forced expiratory flow

  • PEFR: peak expiratory flow rate

  • VC: vital capacity

  • FVC: forced vital capacity

  • In all 11 trials the randomisation method was unknown