Effect of placebo, medroxyprogesterone acetate (MPA), acetazolamide (ACET) and combined drug therapy (MPA/ACET) on ventilatory parameters and respiratory muscle strength
| Placebo# (T2) | ACET¶ (T3A) | MPA+ (T3M) | MPA/ACET# (T4) | |
| V'E L·min−1 | 9.3±0.5 | 9.5±0.9 | 10.2±0.6 | 11.2±0.8§,ƒ |
| VT L | 0.6±0.06 | 0.8±0.2 | 0.6±0.04 | 0.7±0.1§ |
| P0.1 at rest kPa | 0.5±0.04 | 0.5±0.03 | 0.6±0.05 | 0.5±0.04 |
| SHCVR L·min−1·kPa−1 | 3.7±0.6 | 5.5±1.4 | 4.8±1.4 | 5.8±1.0§ |
| BHCVR kPa | 2.9±0.5 | 3.6±0.4 | 2.8±0.5 | 2.9±0.3 |
| SHC,P0.1 kPa·kPa−1 | 0.3±0.04 | 0.2±0.04 | 0.4±0.08 | 0.4±0.04 |
| BHC,P0.1 kPa | 4.2±0.3 | 3.7±0.3 | 3.6±0.4 | 2.9±0.3 |
| SHVR L·min−1/% | −0.13±0.03 | −0.20±0.05 | −0.40±0.11 | −0.40±0.07§ |
| SH,P0.1 kPa/% | −0.01±0.0 | −0.01±0.0 | −0.02±0.01 | −0.03±0.01§ |
| PI,max kPa | 5.7±0.5 | 6.3±0.8 | 5.4±0.5 | 6.7±0.7§ |
| PE,max kPa | 9.3±0.7 | 10.0±1.1 | 8.6±0.8 | 9.6±0.7 |
Data are presented as mean±sem
V'E: minute ventilation
VT: tidal volume
P0.1 at rest: mouth occlusion pressure at rest
SHCVR: slope of the ventilatory carbon dioxide (CO2) response curve (V'E/carbon dioxide tension in arterial blood (Pa,CO2))
BHCVR: apnoeic threshold or extrapolated end-tidal CO2 tension at zero ventilation (x-intercept)
SHC,P0.1: slope of the mouth occlusion response to CO2 (P0.1/Pa,CO2)
BHC,P0.1: x-intercept of the mouth occlusion pressure response to CO2
SHVR: slope of the hypoxic ventilatory response (V'E/arterial oxygen saturation (Sa,O2))
SH,P0.1: slope of the mouth occlusion response to hypoxia (P0.1/Sa,O2)
PI,max: inspiratory mouth occlusion pressure
PE,max: expiratory mouth occlusion pressure
#: n=17
¶: n=9
+: n=8
§: p<0.025 any treatment versus placebo
ƒ: p<0.025 combined treatment versus ACET