FEV1 L | FVC L | PEF L·s−1 | FEF25 L·s−1 | FEF50 L·s−1 | FEF75 L·s−1 | |
Perinatal factors | ||||||
Mother smoked during pregnancy | −0.061 (0.043) | −0.032 (0.048) | −0.257 (0.131)* | −0.290 (0.129)* | −0.127 (0.111) | −0.047 (0.069) |
Being first-born | 0.090 (0.042)* | 0.089 (0.047)¶ | 0.358 (0.128)* | 0.311 (0.126)* | 0.092 (0.108) | 0.023 (0.067) |
Birth weight, per 100 g increase | 0.013 (0.004)* | 0.015 (0.005)* | 0.021 (0.013)¶ | 0.043 (0.012)* | 0.026 (0.011)* | 0.011 (0.007)¶ |
Other potential risk factors | ||||||
Severe respiratory tract infection# | −0.170 (0.062)* | −0.075 (0.070) | −0.627 (0.189)* | −0.665 (0.187)* | −0.408 (0.160)* | −0.177 (0.100)¶ |
Current smoker | 0.030 (0.046) | 0.098 (0.052)¶ | 0.035 (0.140) | 0.117 (0.139) | −0.100 (0.119) | −0.093 (0.74) |
Family history asthma | −0.008 (0.055) | 0.001 (0.062) | −0.403 (0.169)* | −0.440 (0.167)* | −0.230 (0.144) | 0.005 (0.089) |
Family history allery | 0.048 (0.042) | 0.008 (0.048) | 0.106 (0.129) | 0.227 (0.128)¶ | 0.143 (0.110) | 0.071 (0.086) |
Asthmatic symptoms | −0.085 (0.061) | 0.004 (0.068) | −0.171 (0.186) | −0.312 (0.184)¶ | −0.303 (0.158)¶ | −0.195 (0.098)* |
Bronchitic symptoms | −0.093 (0.048)¶ | 0.038 (0.054) | −0.324 (0.146)* | −0.419 (0.144)* | −0.208 (0.124)¶ | −0.149 (0.077)¶ |
Data are presented as B (SE)
FEV1: forced expiratory volume in one second
FVC: forced vital capacity
PEF: peak expiratory flow
FEF25, FEF50, FEF75: forced expiratory flow when 25%, 50% and 75% of the forced expiratory vital capacity has been exhaled
Multiple linear regression analysis estimating the effect of perinatal factors (mother smoked during pregnancy, being first‐born and birth weight) on level of lung function, with adjustment for other potential risk factors (severe respiratory tract infection in the first year of life, current smoking, asthmatic and bronchitic symptoms, family history for asthma or allergy, sex (not shown), age (not shown), height (not shown)
*: p<0.05
¶: p<0.10
#: in the first year of life. n=590