Table 3—

Independent associations of perinatal factors and the lung function measurements at a young adult age, with adjustment for other potential risk factors

FEV1 LFVC LPEF L·s−1FEF25 L·s−1FEF50 L·s−1FEF75 L·s−1
Perinatal factors
 Mother smoked during pregnancy−0.061 (0.043)−0.032 (0.048)−0.257 (0.131)*−0.290 (0.129)*−0.127 (0.111)−0.047 (0.069)
 Being first-born0.090 (0.042)*0.089 (0.047)0.358 (0.128)*0.311 (0.126)*0.092 (0.108)0.023 (0.067)
 Birth weight, per 100 g increase0.013 (0.004)*0.015 (0.005)*0.021 (0.013)0.043 (0.012)*0.026 (0.011)*0.011 (0.007)
Other potential risk factors
 Severe respiratory tract infection#−0.170 (0.062)*−0.075 (0.070)−0.627 (0.189)*−0.665 (0.187)*−0.408 (0.160)*−0.177 (0.100)
 Current smoker0.030 (0.046)0.098 (0.052)0.035 (0.140)0.117 (0.139)−0.100 (0.119)−0.093 (0.74)
 Family history asthma−0.008 (0.055)0.001 (0.062)−0.403 (0.169)*−0.440 (0.167)*−0.230 (0.144)0.005 (0.089)
 Family history allery0.048 (0.042)0.008 (0.048)0.106 (0.129)0.227 (0.128)0.143 (0.110)0.071 (0.086)
 Asthmatic symptoms−0.085 (0.061)0.004 (0.068)−0.171 (0.186)−0.312 (0.184)−0.303 (0.158)−0.195 (0.098)*
 Bronchitic symptoms−0.093 (0.048)0.038 (0.054)−0.324 (0.146)*−0.419 (0.144)*−0.208 (0.124)−0.149 (0.077)
  • Data are presented as B (SE)

  • FEV1: forced expiratory volume in one second

  • FVC: forced vital capacity

  • PEF: peak expiratory flow

  • FEF25, FEF50, FEF75: forced expiratory flow when 25%, 50% and 75% of the forced expiratory vital capacity has been exhaled

  • Multiple linear regression analysis estimating the effect of perinatal factors (mother smoked during pregnancy, being first‐born and birth weight) on level of lung function, with adjustment for other potential risk factors (severe respiratory tract infection in the first year of life, current smoking, asthmatic and bronchitic symptoms, family history for asthma or allergy, sex (not shown), age (not shown), height (not shown)

  • *: p<0.05

  • : p<0.10

  • #: in the first year of life. n=590