Table 1—

Unadjusted effects of cytokine responses and bronchiolitis on asthma and wheeze

AsthmaWheeze
OR95% CIp‐valueOR95% CIp‐value
IL‐4 FG1.05(0.71–1.56)0.811.08(0.78–1.49)0.64
IL‐4 RSV1.16(0.77–1.77)0.481.11(0.79–1.56)0.54
IL‐4 Fel d#1.73(1.06–2.84)0.031.70(1.14–2.55)0.01
IL‐4 Bet v1.53(0.97–2.41)0.071.35(0.92–1.99)0.12
IL‐4 Der p1.04(0.63–1.73)0.870.95(0.61–1.48)0.83
IFN‐γ FG1.00(0.70–1.43)0.991.06(0.78–1.44)0.70
IFN‐γ RSV1.25(0.65–2.40)0.511.17(0.71–1.93)0.55
IFN‐γ Fel d1.09(0.79–1.50)0.610.91(0.72–1.16)0.45
IFN‐γ Bet v0.87(0.67–1.13)0.300.82(0.66–1.02)0.08
IFN‐γ Der p1.13(0.85–1.52)0.401.03(0.83–1.29)0.78
Bronchiolitis#25.19(3.07–206.37)0.00357.80(7.24–461.44)0.0005
  • Logistic regression analysis was used to identify the odds ratios (OR) associated with a history of bronchiolitis, or current interleukin (IL)‐4 or interferon (IFN)‐γ responses of peripheral blood mononuclear cells stimulated with the viral antigens FG, respiratory syncytial virus (RSV), and airborne allergens Fel d, Bet v and Der p. The ORs shown represent the increase in odds for a one log unit increase of antigen specific IL‐4 secreting cells or IFN‐γ secreting cells

  • CI: confidence interval

  • #: significant risk factors (p<0.05)