Table 5—

Intubation rate, outcome, length of stay (LOS) and mean time of application of noninvasive positive-pressure ventilation (NPPV) in the literature

First author [ref. no]StudyAetiology of ARFPatients nPHPa,CO2 mmHgDuration of NPPV applicationLOS ICU daysIntubation nSurvival rate %
Meduri 30OHypercapnic ARF187.2972251NA594
Brochard 31HMCOPD137.29657.633d185
Kramer 7PRARF167.2774.314.43.8±1.4NA593.7
Barbe 12PRCCOPD347.33566300100
Fernandez 32OCOPD127.19928±4NA7.6±1.7393
Lin 10PRAPO507.4032.96NA4±3892
Mehta 13PRCAPO147.25567.1±4.7NA2.3±3.7193
Wysocki 33PRCCOPD217.39447.6±11.81.5±117±191367
Poponick 34OARF587.2675.30.5NA4.21396.5
Celikel 15PRCHypercapnic ARF157.286726.7±16.1NA11.71100
Wood 16PRCARF167.3556.5NA5.8±5.5775
Plant 19PRCCOPD1187.3261.783NA1889.8
Antonelli 35PRCARF327.4538NA9±71071.8
ThysPRPCCOPD and APO107.28571.59±0.4812.7±3.5080
Thys placeboPRPCCOPD and APO107.24610.48±0.2815.4±5.6390
  • O: open study

  • HM: historical matched

  • PR: prospective randomised

  • PRC: prospective randomised controlled

  • PRPC: prospective randomised placebo-controlled

  • ARF: acute respiratory failure

  • COPD: chronic obstructive pulmonary disease

  • APO: acute pulmonary oedema

  • NA: not available

  • ICU: intensive care unit

  • Previous studies: patients with active NPPV

  • Present study: patients with active and placebo NPPV

  • 1 mmHg=0.133 kpA