Tumour necrosis factor (TNF)a and human leukocyte antigen (HLA)-DR polymorphic genes in pulmonary responders to chemotherapy
| PR | PNR | Chi-squared | p-value | Pc | |||
| n | % | n | % | ||||
| Subject n | 20 | 21 | |||||
| TNF | |||||||
| a2 | 13 | 65 | 4 | 19 | 8.9122 | 0.0028 | 0.033 |
| a3 | 0 | 0 | 1 | 5 | 0.0006 | 0.9803 | |
| a4 | 1 | 5 | 6 | 29 | 2.5275 | 0.1118 | |
| a5 | 2 | 10 | 2 | 10 | 0.2257 | 0.6346 | |
| a6 | 8 | 40 | 3 | 14 | 3.4503 | 0.0632 | |
| a7 | 1 | 5 | 5 | 24 | 1.5908 | 0.2072 | |
| a8 | 0 | 0 | 1 | 5 | 0.0006 | 0.9802 | |
| a9 | 3 | 15 | 3 | 14 | 0.1423 | 0.7059 | |
| a10 | 6 | 30 | 7 | 33 | 0.0525 | 0.8186 | |
| a11 | 5 | 25 | 6 | 29 | 0.0665 | 0.7964 | |
| a12 | 0 | 0 | 1 | 5 | 0.0006 | 0.9802 | |
| a13 | 0 | 0 | 0 | 0 | |||
| TNF-308*2 | 6 | 30 | 3 | 14 | 0.7017 | 0.4022 | |
| HLA-DRB1*03 | 6 | 30 | 4 | 19 | 0.2047 | 0.6509 | |
| HLA-DRB1*15 | 10 | 50 | 3 | 14 | 6.0341 | 0.0140 | 0.18 |
| HLA-DRB1*15 and/or TNFa2 | 17 | 85 | 6 | 28.6 | 13.244 | 0.0002 | 0.0068 |
PR: pulmonary responders
PNR: pulmonary nonresponders
Pc: Bonferroni correction