Table 1—

Lungs function parameters at rest and exhated nitric oxide measurement

VariablePatients nWeekP-value#
816
FEV1 % pred
 All3183.1±2.093.4±2.4**88.2±3.30.0124
 Steroids1592.3±2.7+
 No steroids1692.3±2.9
MMEF % pred
 All3165.3±2.981.6±4.6**77.4±4.50.0041
 Steroids1581.3±5.0+
 No steroids1683.3±7.1
FVC % pred
 All3185.7±2.090.5±2.588.7±1.80.1132
 Steroids1589.8±2.8ƒ
 No steroids1687.8±2.2
eNO ppb
 All3114.8±1.97.6±0.8***14.0±1.2+0.0001
 Steroids157.7±1.2§
 No steroids1613.8±2.5
  • Values are presented as mean±sem of n patients

  • #: first repeated measures analysis of variance was calculated over the different time points. If p<0.05, a Newman-Keuls post-tests was used for comparisons within a treatment group

  • **: p<0.01

  • ***: p<0.001 (before treatment to after run-in)

  • : p<0.05 (before treatment to after wash-out)

  • ƒ: p<0.001 (after run-in to after washout) If p>0.05, no further calculations were made. For analysis of differences between both treatment groups (steroids and no sterioids), the unpaired t-test was used: +: ns; §: p<0.05