Table 1—

Value of different diagnostic methods in invasive pulmonary aspergillosis

Thoracic CT scan
 Halo/air crescent>8060–98Specificity only assessed in a few studies, findings depend on the disease stage
 Galactomannan Antigen
  Latex agglutination (Pastorex®)13–9586–100Cross reactivity against penicillium
  ELISA (Platelia®)90–9395–98ppv 87–93, npv 95–98,
False positive rate 8–14
To measure 1–3 times weekly
 BDG-ELISA16–9076–100,ppv 59, npv 97
 PCR100,65–92,ppv 15–44, npv 100
Useful to exclude aspergillus
Bronchoscopy with BAL
 Culture43100Use of Sabouard medium preferred
 Galactomannan antigen0–8065–95Highly variable results
 PCR67–10055–95,ppv 20–46, npv 93–100
Useful to exclude aspergillus
  • Data are presented as % unless otherwise stated

  • CT: computed tomography

  • ELISA: Enzyme-linked immunosorbent assay

  • BDG: (1–3)‐β‐d‐glucan

  • PCR: Polymerase chain reaction

  • BAL: bronchoalveolar lavage

  • ppv: positive predictive value

  • npv: negative predictive value