Table 3—

Forced expiratory volume in one second (FEV1) after exercise for the three different time intervals between inhalation of the study drug and start of exercise

Time interval
5 min30 min60 minp-value#
Maximum decrease in FEV1 %
 Placebo−22.0 (−26.2–−17.7)−22.4 (−27.4–−17.5)−25.1 (−30.1–−20.1)ns
 Terbutaline−5.1 (−8.6–−1.6)−6.3 (−9.4–−3.2)−8.5 (−11.8–−5.1)0.09
 Formoterol1.8 (−4.2–0.7)−5.7 (−7.9–−3.5)−5.6 (−8.4–−2.7)0.006
 Salmeterol−5.9 (−9.9–−1.9)−7.6 (−10.8–−4.5)−7.0 (−10.5–−3.4)ns
Maximum decrease in FEV1 mL
 Placebo−780 (−959–−601)−792 (−969–−614)−894 (−1086–−702)ns
 Terbutaline−208 (−335–−82)−256 (−365–−146)−361 (−506–−216)0.034
 Formoterol−89 (−195–17)−233 (−334–−133)−243 (−376–−110)0.018
 Salmeterol−242 (−404–−80)−296 (−429–−164)−276 (−428–−125)ns
  • All data are presented as mean (95% confidence interval) unless otherwise stated

  • #: analysis of variance between the three time intervals