Details of 11 patients with cystic fibrosis and allergic bronchopulmonary aspergillosis showing a pathological adrenocorticotropic hormone test
| Patient | Itraconazole treatment | Time months | p‐ACTH pmol·L−1# | p‐cortisol nmol·L−1 | |||||
| no. | Age | Median dose | Duration | Accumulated dose | 0 min | 30 min | 60 min | ||
| yrs | mg·day−1 | months | mg | ||||||
| 1 | 24 | 400 | 4 | 48 | 0 | <1 | <15 | 47 | 16 |
| 3 | 1 | 20 | 55 | 66 | |||||
| 6 | 6 | 43 | 71 | 86 | |||||
| 9 | 10 | 39 | 63 | 55 | |||||
| 2¶ | 21 | 300 | 100 | 669 | 0 | <1 | <30 | 143 | 183 |
| 2 | 1 | 152 | 367 | 459 | |||||
| 3+ | 20 | 200 | 77 | 635 | 0 | <1 | <15 | <15 | <15 |
| 4 | 4 | 189 | 320 | 367 | |||||
| 5 | 8 | 170 | 290 | 321 | |||||
| 8 | 59 | 222 | 239 | ||||||
| 10 | <30 | 140 | 155 | ||||||
| 4+ | 19 | 500 | 48 | 768 | 0 | <15 | <15 | <15 | |
| 1 | 4 | 266 | 280 | 372 | |||||
| 2 | 7 | 223 | 313 | 310 | |||||
| 5 | 19 | 305 | 366 | 382 | |||||
| 7 | 191 | 208 | 213 | ||||||
| 5 | 18 | 200 | 96 | 678 | 0 | <1 | <15 | 71 | 122 |
| 3 | 2 | 114 | 186 | 229 | |||||
| 6 | 153 | 218 | 243 | ||||||
| 10 | 163 | 292 | 324 | ||||||
| 6 | 300 | 38 | 264 | 0 | 1 | <15 | <15 | <15 | |
| 2 | 37 | 28 | 25 | ||||||
| 3 | 3 | <15 | <15 | <15 | |||||
| 5 | 1 | <15 | <15 | <15 | |||||
| 9 | 85 | 112 | 123 | ||||||
| 7§ | 9 | 100 | 1 | 3 | 0 | <1 | <15 | <15 | 25 |
| 8 | 13 | 600 | 3 | 54 | 0 | <15 | 36 | 55 | |
| 3 | 1 | 12 | 181 | 220 | |||||
| 6 | 259 | 324 | 372 | ||||||
| 9 | 233 | 314 | 352 | ||||||
| 9 | 20 | 400 | 55 | 788 | 0 | 3 | 103 | 285 | 348 |
| 2 | 3 | 190 | 277 | 368 | |||||
| 7 | 6 | 271 | 453 | 521 | |||||
| 10 | 15 | 200 | 75 | 420 | 0 | 7 | 60 | 342 | 405 |
| 2 | 11 | 208 | 362 | 438 | |||||
| 3 | 4 | 63 | 286 | 340 | |||||
| 6 | 13 | 239 | 401 | 439 | |||||
| 11ƒ | 13 | 100 | 57 | 255 | 0 | <1 | |||
| 1 | 1 | <30 | 57 | 81 | |||||
| 7 | 61 | 82 | 80 | ||||||
The daily dose, accumulated dose and duration of itraconazole treatment, results of plasma ACTH and spontaneous and stimulated plasma-cortisol measurements after 30 and 60 min are shown. All patients were treated with budesonide. Itraconazole treatment was withdrawn at time=0. P‐ACTH and p‐cortisol were measured during the following period (given as number of months after time=0)
p‐ACTH: plasma adrenocorticotropic levels
p‐cortisol: plasma cortisol levels
#: p‐ACTH normal range 2–10 pmol·L−1
¶: patient receiving concomitant treatment with prednisolone (10 mg·2nd day−1)
+: Clanthromycin (500 mg·day−1)
§: prednisolone (30 mg·day−1)
ƒ: prednisolone (7.5 mg·2nd day−1)