Combined effects of α1-antitrypsin (α1-AT) plasma levels and exposure to truck traffic density on pulmonary function adjusted for environmmental tobacco smoke (ETS)
| Subjects n | FVC | FEV1 | FEV1/FVC | PEF | MEF75 | MEF50 | MEF25 | MMEF | |
| α1-AT normal Truck traffic unexposed | 373 | 101.1±0.6 | 99.6±0.6 | 98.7±0.4 | 97.5±1.1 | 97.0±1.1 | 96.5±1.4 | 95.0±2.0 | 95.4±1.5 |
| α1-AT normal Truck traffic exposed | 185 | 102.4±0.8 | 100.5±0.8 | 98.4±0.6 | 97.8±1.5 | 97.2±1.4 | 96.8±1.8 | 96.0±2.5 | 95.8±2.1 |
| α1-AT low Truck traffic unexposed | 13 | 95.1±3.2 | 94.2±3.2 | 99.1±2.3 | 98.5±6.1 | 100.0±6.0 | 87.2±7.3 | 85.5±10.7 | 85.7±8.4 |
| α1-AT low Truck traffic exposed | 8 | 95.7±3.5 | 90.5±3.5 | 94.8±2.5 | 93.7±6.6 | 95.4±6.5 | 79.9±7.9 | 72.3±12.0 | 76.2±17.1 |
Data are presented as % predicted; least square mean±se (from the cell means model, which includes an α1-AT ETS interaction term)
FVC: forced vital capacity
FEV1: forced expiratory volume in one second
PEF: peak expiratory flow
MEF75, MEF50 and MEF25: maximum expiratory flow at 75%, 50% and 25% of vital capacity, respectively
MMEF: maximal midexpiratory flow
α1-AT normal: >116 mg·dL−1
α1-AT low: ≤116 mg·dL−1
truck traffic unexposed: ≤730 trucks·day−1 at streets in a radius of 100 m around the children's homes. Truck traffic exposed: >730 trucks·day−1 at streets in a radius of 100 m around the children's homes