Pulmonary function in children according to genotype and plasma level of α1-antitrypsin (α1-AT)
| Lung function | Genotype | Plasma levels | |||
| PiMS | PiMZ | Others | α1-AT≤116 mg·dL−1 % pred; mean±se | α1-AT>116 mg·dL−1 % pred; mean±se | |
| Subjects n | 61 | 41 | 1595 | 68 | 1623 |
| FVC | 99.8±1.4 | 99.9±1.7 | 100.2±0.3 | 100.6±1.4 | 100.2±0.3 |
| FEV1 | 100.0±1.3 | 98.8±1.6 | 99.8±0.3 | 98.5±1.3 | 99.9±0.3 |
| FEV1/FVC | 100.4±0.8 | 99.1±1.0 | 99.9±0.2 | 98.1±0.7 ¶ | 99.9±0.2 |
| PEF | 101.2±2.5 | 97.7±3.0 | 100.3±0.5 | 96.2±1.9 ¶ | 100.5±0.5 |
| MEF75 | 101.7±2.4 | 95.4±3.0 | 99.6±0.5 | 93.8±1.8 ¶ | 99.8±0.5 |
| MEF50 | 99.9±2.9 | 90.6±3.5*,# | 99.0±0.6 | 90.0±2.9 ¶ | 99.0±0.6 |
| MEF25 | 98.1±4.1 | 95.1±5.1 | 99.1±0.8 | 91.2±3.4 | 99.0±0.8 |
| MMEF | 101.6±3.2 | 94.6±3.8 | 99.0±0.6 | 92.9±2.5 ¶ | 99.1±0.6 |
Data are presented as % predicted; least square mean±se unless otherwise stated
FVC: forced vital capacity
FEV1: forced expiratory volume in one second
PEF: peak expiratory flow
MEF75, MEF50, MEF25: maximum expiratory flow at 75%, 50% and 25% of vital capacity, respectively
MMEF: maximal midexpiratory flow
Pi: protein inhibitor
*: p<0.05 in one-way analysis of variance: PiMZ in comparison to children with other genotypes
#: p<0.05 in one-way ANOVA: PiMZ in comparison to PiMS
p-values corrected for multiple comparisons with the stepwise Bonferroni method 20
¶: p<0.05 in t-test: children with α1-AT≤116 mg·dL−1 in comparison to children with α1-AT levels >116 mg·dL−1