Table 2—

Total and individual symptom scores after 12 weeks of treatment

Parameter	Treatment	Mean	Difference relative to placebo
Parameter	Treatment	Mean	%	95% CI	p-value
Sleep disturbance	Formoterol 4.5 µg	1.64	99.32	93.39–105.62	0.8271
	Formoterol 9 µg	1.66	100.60	94.51–107.08	0.8506
	Formoterol 18 µg	1.56	94.29	88.71–100.22	0.0588
	Placebo	1.65
Breathlessness	Formoterol 4.5 µg	2.29	96.75	91.13–102.72	0.2784
	Formoterol 9 µg	2.19	92.65	87.20–98.44	0.0136
	Formoterol 18 µg	2.15	90.76	85.53–96.31	0.0014
	Placebo	2.37
Cough	Formoterol 4.5 µg	2.01	96.64	90.75–102.91	0.2864
	Formoterol 9 µg	2.03	97.78	91.73–104.23	0.4905
	Formoterol 18 µg	2.03	97.57	91.67–103.85	0.4391
	Placebo	2.08
Chest tightness	Formoterol 4.5 µg	1.81	96.56	90.59–102.93	0.2822
	Formoterol 9 µg	1.66	88.98	83.40–94.93	0.0004
	Formoterol 18 µg	1.72	91.99	86.35–98.01	0.0099
	Placebo	1.87
Total symptom score^#	Formoterol 4.5 µg	4.68	94.05	86.23–102.58	0.1660
	Formoterol 9 µg	4.58	92.16	84.39–100.64	0.0691
	Formoterol 18 µg	4.34	87.25	80.06–95.09	0.0019
	Placebo	4.97

Data are presented as adjusted geometric means unless otherwise stated
CI: confidence interval
^#: adjusted geometric means calculated from the multiplicative analysis of the average total symptom score