Group | BL | LL | 15 min | 30 min | 60 min | 90 min | 120 min |
I | 23±3 | 24±3* | 28±1* | 30±2* | 28±3* | 29±3* | |
II | 31±6 | 70±24# | 77±27# | 76±31# | 83±36# | 84±36# | 70±20# |
III | 38±15 | 47±7¶ | 36±10¶ | 31±5¶ | 33±6¶ | 29±5¶ | 30±6¶ |
IV | 47±9 | 63±8 | 51±5 | 49±6 | 50±4 | 44±4 | 44±7 |
V | 37±9 | 53±13 | 41±10 | 46±13 | 50±12 | 49±12 | 48±13 |
Data is presented as mean±sd
BL: before lavage
LL: repeated lavage with saline to induce lung injury
Group I: sham
Group II: control
Group III: treated with surfactant
Group IV: treated with surfactant suspended in 4:1 saline-iodixanol
Group V: treated with surfactant suspended in 1:1 saline-iodixanol
*: p<0.05 versus Group II, IV and V
#: p<0.05 versus Group I, III, IV and IV
¶: p<0.05 versus Group IV and V