Table 3—

Ciliary function and ultrastructural analysis pre and post virus or sham inoculation

CBF HzCiliary dyskinesia scoreDynein arm defects %Microtubule defects %Central microtubule defects %Ciliary orientation °
Corona
 Day 011.3 (8.6–14.0)0.2 (0–0.5)1.3 (0.3–2.3)2.6 (1.4–3.8)0.3 (0.0–0.6)10.6 (10.1, 11.1)
 Day 39.4 (7.2–11.6)1.1 (0.5–1.7)*2.9 (0.8–5.0)4.7 (3.2–6~2)*1.0 (0.1–1.9)11.4 (10.4, 12.4)
Sham
 Day 011.9 (11.6–12.2)0.1 (0.0–0.0)0.9 (0.0–2 2)2.2 (1.0–3.4)0.0 (0.0–0 0)10.7 (10.0–11.4)
 Day 310.8 (10.1–11.5)0.2 (0.0–0.4)1.2 (0.1–2.3)2.3 (0.8–3.8)0.0 (0.0–0 0)11.0 (10.3–11.7)
Group difference#
 Corona – sham−0.8 (−7.9–6.3)−0.8 (−1.5–−0.1)*1.1 (−2.8–5.0)1.8 (0.1–3.4)*0.8 (−0.6–2.1)0.7 (−1.1–2.5)
  • Data are presented as mean (95% confidence interval)

  • CBF: ciliary beat frequency

  • #: difference between changes from baseline in the two groups, i.e. (day 3 − day 0)corona−(day 3 − day 0)sham

  • *: p < 0.05