Maximal aggregation (%) and PFA closure time in response to the different agonists before and after inhalation of iloprost
| Baseline | 30 min | 4 h | 6 h | p-value# | |
| Maximal aggregation % | |||||
| ADP 2 µM | 47.3±9.1 | 20.2±8.9* | 35.8±8.6* | 41.6±9.2 | 0.005 |
| ADP 6 µM | 73.2±4.2 | 60.1±4.5* | 61.6±6.2* | 63.1±5.1 | 0.01 |
| EPI 1.25 µM | 49.3±9.1 | 33.9±9.3* | 37.1±10.4* | 41.5±8.9 | 0.009 |
| EPI 5 µM | 75.8±3 | 58.6±6.1* | 55±7.3* | 65.9±6.1 | 0.01 |
| Coll 2.5 µg·mL−1 | 80±2.2 | 70.3±3.7* | 77.6±2.3 | 76.3±3.5 | 0.04 |
| Coll 5 µg·mL−1 | 79.5±2.2 | 76.8±2.4 | 72.8±4.6 | 78.9±2.3 | 0.22 |
| AA 0.5 mg·mL−1 | 76±3.3 | 64.3±6.5 | 61.9±7.2 | 71.3±3.1 | 0.05 |
| PFA closure times | |||||
| EPI | 168.6±19 | 188.3±21.3 | 194.6±22.1 | 192.7±23 | 0.38 |
| ADP | 79.8±6.3 | 81.5±6 | 89.3±3.5 | 89.7±5.4 | 0.08 |
Data are presented as mean±sem unless otherwise stated
ADP: adenosine diphosphate
EPI: epinephrine
Coll: collagen
AA: arachidonic acid
PFA: Platelet Function Analyser
#: p-value as determined by analysis of variance
*: p<0.05