Table 1—

Relationship between matrix metalloproteinases (MMPs) elastase and pathological features of diffuse alveolar damage

MMP-;2MMP-;9Elastase
rsp-;valversp-;valveRsp-;valve
Exudative phase
 Epithelial destruction0.51*0.0130.64#0.0010.64#0.001
 Capillary congestion0.60#0.0030.80#<0.00010.69#0.0003
 Interstitial oedema0.55**0.0070.66#0.0010.67#0.0004
 Alveolar oedema0.45*0.0300.56**0.0050.65#0.0008
 Hemorrhage0.40ns0.53*0.0100.70#0.0002
 Mononuclear infiltration0.37ns0.65#0.0010.63#0.001
 Polymorphonuclear infiltration0.46*0.0260.57#0.0050.66#0.0006
 Interlobular septal thickening0.44*0.0350.62#0.0020.55**0.006
 Hyaline membrane0.44*0.0340.71#0.00010.77#<0.0001
 Microatelectasis0.45*0.0320.66#0.00050.69#0.0003
Proliferative phase
 Type II pneumocyte hyperplasia0.41ns0.58#0.0040.66#0.0007
 Fibroblast proliferation0.27ns0.57#0.0050.62#0.002
Fibrotic phase
 Interstitial collagen depositionNDNDND
  • rs: Spearmen's correlation coefficient

  • ns: nonsignificant

  • ND: not defected

  • *: p<0.05 cornpared with MMP-;2 or -;9

  • **: p<0.01 corrpored with MMP-;2 or -;9

  • #: p<0.005 corrpored with MMP-;2 or -;9