Table 3—

Pharmacokinetic parameters

Once-daily groupMeanConfidence limit
−95%+95%
 60-min level mg·L−119.916.923.0
 6-h level mg·L−12.72.03.5
 Time when level equaled 1 mg·L−1 h10.47.912.9
 K·h−10.360.320.40
 Half-life h1.91.72.2
 Maximum tobramycin level mg·L−129.124.533.7
 Repeat 60-min level mg·L−125.619.531.7
 Repeat 6-h level mg·L−13.32.24.5
 Time when level equaled 1 mg·L−1 h9.96.713.2
 K0.380.320.44
 Half-life h2.01.52.4
 Maximum tobramycin level mg·L−141.029.952.2
Twice-daily group
 Peak level mg·L−110.58.912.1
 Trough level mg·L−11.31.11.6
 K·h−10.370.340.40
 Half-life h1.91.72.0
 Repeat peak level mg·L−19.38.010.6
 Repeat trough level mg·L−11.30.91.7
 K0.360.280.44
 Half-life h2.01.52.5
  • K: elimination rate constant