Table 2—

Responses to 200 µg salbutamol metered dose inhaler

Absolute ΔΔ % predΔ %
FEV1 L0.09±0.01#3.4±0.412±1
FEV1/FVC %−2.1±0.4#−2.9±0.7−5±1
FVC L0.32±0.03#9.2±0.718±1
SVC L0.31±0.03#7.2±0.712±1
IC L0.19±0.04#8.1±1.515±3
TLC L−0.12±0.04**−2.5±0.7−2±1
RV L−0.37±0.05#−17.9±2.0−7±1
FRC L−0.31±0.05#−9.9±1.4−5±1
Severe subgroup
 FEV1 L0.10±0.01#3.7±0.515±2*
 FEV1/FVC %−2.4±0.7**−3.1±1.0−6±2
 FVC L0.38±0.04#10.0±0.923±2**
 SVC L0.32±0.04#8.3±1.016±2*
 IC L0.27±0.04#11.1±1.7§22±4**
 TLC L−0.19±0.06**−3.2±1.0−2±1
 RV L−0.51±0.09#−22.7±3.5*−8±1
 FRC L−0.45±0.08#−13.5±2.3*−7±1*
Moderate subgroup+
 FEV1 L0.08±0.01#3.4±0.610±2
 FEV1/FVC %−1.8±0.5**−1.8±0.5−4±1
 FVC L0.28±0.04#8.6±1.015±2
 SVC L0.21±0.04#6.4±1.010±2
 IC L0.14±0.05**5.8±2.210±3
 TLC L−0.08±0.05−1.9±1.0−1±1
 RV L−0.27±0.04#−14.2±2.3−6±1
 FRC L−0.21±0.06#−7.1±1.8−4±1
  • Data are presented as mean ±sem

  • FEV1: forced expiratory volume in one second

  • FVC: forced vital capacity

  • SVC: slow vital capacity

  • IC: inspiratory capacity

  • TLC: total lung capacity

  • RV: residual volume

  • FRC: functional residual capacity

  • % pred: percentage of predicted

  • : n=36

  • +: n=48

  • FRC was plethysmographically determined

  • *: p<0.05, **: p<0.01, #: p<0.0005, significant difference pre- to postbronchodilator (noted only in Absolute Δ column), or in severe versus moderate subgroups (comparisons of % pred values and Δ % only)

  • §: p=0.08