Table 2

Survival analysis for different subgroups

GroupsMedian survival (months)
ExpressionNo expressionp-value (Logrank-Mantel-Cox-Test)
BAX14 (30)6 (31)<0.0004
 stages I–III group18 (18)12 (10)<0.037
 stage IV group6 (12)3 (21)<0.017
 therapy group16 (25)8 (20)<0.005
 best supportive care5 (5)2 (11)ns
  p53wt and18 (13)8 (16)
  p53mut12 (17)3 (15)<0.0003
  p53pos and16 (16)4 (14)
  p53neg12 (13)9 (17)<0.0005
p16INK4A154<0.0001
 stages I–III group18 (18)12 (10)<0.037
 stage IV group9 (14)2 (19)<0.028
 therapy group15 (26)6 (19)<0.0004
 best supportive care5 (9)2 (7)<0.018
  p53wt and15 (19)5 (10)
  p53mut13 (16)3 (16)<0.0006
  p53pos and16 (17)5 (14)
  p53neg12 (18)3 (12)<0.0001
  BAXpos and16 (20)6 (10)
  BAXneg12 (15)2 (16)<0.0002
  • wt: wild type

  • mut: mutated

  • pos: positive

  • neg: negative

  • ns: nonsignificant