Table 2

Baseline characteristics by diagnosis

CharacteristicUIPFibrotic NSIPCellular NSIPRBILD/DIPANOVA*
mean±sdmean±sdmean±sdmean±sdp-value
Sex male/female50/5616/123/213/90.73#
Age at biopsy yrs62±1156±1150±949±10<0.0001
Time since symptom onset yrs2.8±2.92.2±3.41.8±2.02.8±2.40.52
Weight kg86±1887±1885±1986±180.99
Smokers % 60 71 40 59 0.51#
Cigarette consumption pack-yrs18±2224±257±1422±260.32
Dyspnoea
 LOD10±510±45±414±40.18
 BDI6±25±28±3NA0.36
 OCD48±1946±1867±25NA0.34
Spirometry
 FVC L2.49±0.932.68±0.592.81±1.472.91±0.980.40
 % pred67±1973±1572±2478±200.18
 FEV1 L2.04±0.732.10±0.492.24±0.942.16±0.770.87
 % pred77±2178±1978±2278±260.99
 TLC L4.05±1.194.47±1.094.68±2.195.18±1.510.02
 % pred73±1678±1978±2278±260.02
DL,CO mL·min−1·mmHg−112.8±5.211.8±3.216.9±4.916.4±3.10.01
 % pred51±1751±1469±1463±140.02
HRCT Score
 Alveolar1.85±0.902.62±1.291.60±2.101.62±1.210.03
 Interstitial1.90±0.720.87±0.620.44±0.410.63±0.42<0.0001
 Total3.75±0.963.49±1.472.04±2.042.54±0.97<0.0001
  • *: the following post hoc comparisons were significant at the p=0.05 level

  • all other comparisons were non-significant: usual interstitial pneumonia (UIP) versus fibrotic nonspecific interstitial pneumonia (NSIP), cellular NSIP and respiratory bronchiolitis interstitial lung disease/desquamative interstitial pneumonia (RBILD/DIP) and fibrotic NSIP versus RBILD/DIP (age)

  • UIP versus RBILD/DIP (total lung capacity (TLC))

  • UIP versus fibrotic NSIP and RBILD/DIP (TLC, percentage of the predicted value (% pred))

  • UIP versus RBILD/DIP and fibrotic NSIP versus cellular NSIP and RBILD/DIP (diffusion capacity of the lung for carbon monoxide (DL,CO))

  • UIP versus cellular NSIP and RBILD/DIP and fibrotic NSIP versus cellular NSIP and RBILD/DIP (DL,CO, % pred)

  • fibrotic NSIP versus UIP and RBILD/DIP (high-resolution) computed tomography score (HRCT score, alveolar) 10

  • UIP versus fibrotic NSIP, cellular NSIP and RBILD/DIP (HRCT, interstitial)

  • and UIP versus fibrotic NSIP, cellular NSIP and RBILD/DIP (HRCT, total)

  • #: Fisher exact test

  • ANOVA: analysis of variance

  • LOD: level of dyspnea [scale] 7

  • BDI: Baseline dyspnea index 8

  • OCD: oxygen consumption diagram 9

  • FVC: forced vital capacity

  • FEV1: forced expiratory volume in one second

  • NA: not available