Chemokine receptor | Cell types | Agonists | Antagonists |
CCR3 | Eosinophil, Th2, mast cell | Eotaxin, eotaxin‐2, RANTES, MCP‐4 | Met-RANTES, UCB 35625, SB 328437 |
CCR2 | Monocyte, mast cell, T‐lymphocyte | MCP‐1, MCP2‐5 | |
CCR4 | Th2 | MDC, TARC |
Several chemokines are likely to be involved in the pathophysiology of asthma. There are three major chemokine receptor targets in asthma, CCR3, which is most advanced in terms of low-molecular-weight inhibitor development, and also CCR2 and CCR4, for which low-molecular-weight inhibitors are currently developed
Th2: type 2 T‐helper lymphocyte
RANTES: regulated on activation, normal T‐cell expressed and secreted
MCP‐4: macrophage chemoattractant protein‐4
MDC: monocyte-derived chemokine
TARC: thymus and activation-dependent chemokine
Met-RANTES: N‐terminally modified RANTES