Table 3—

Clinical parameters of patients referred with questionable Cystic Fibrosis (GF)

QCF-CFQCF-non-CFp-value
Subjects n2446
Age yrs12.17±10.4919.13±11.90.013
Sweat chloride mmol·L−156±1739±18<0.001
FEV1 % pred83.6±19.783.7±32.9NS
Positive sputum clutures49NS
CFTR mutationsW1282X/5T(2)5T/5T(1)<0.001
W1282X/3849+10kbC->T(1)ΔF508(3)0.04
ΔF508/5T(1)5T(3)
D1152H/5T(1)
ΔF508(1)
Male infertility13NS
Pancreatic insufficiency11NS
  • Data are preserted as mean±SD

  • Pseudomonas(5)

  • Hemophilus influenza(5)

  • Moraxella(2)

  • Streptococcus(1)

  • for comparison of the number of patients carrying two CFTR mutations in both groups

  • for comparison of the frequency of the 5T allele in the QCF-CF group to that in the general population. QCF-CF: questionable CF with abnormal potential difference

  • QCF-non-CF: questionable CF with normal potential difference

  • FEV1: forced expiratory volume in one second

  • CFTR: cystic fibrosis transmembrane conductance regulator

  • ns: nonsignificant