Spearman correlation coefficients (rho) for the relationship between high-resolution computed tomography (HRCT) and lung function
HRCT pixel index | ||||
Upper zone | lower zone | |||
Inspiratory | Expiratory | Inspiratory | Expiratory | |
FEV1 | −0.60 | −0.72 | −0.64 | −0.75 |
FEV1/VC | −0.72 | −0.79 | −0.70 | −0.78 |
FEF25%–75% | −0.60 | −0.69 | −0.70 | −0.76 |
sGaw | −0.67 | −0.76 | −0.68 | −0.76 |
TLC | 0.63 | 0.70 | 0.54 | 0.61 |
RV | 0.61 | 0.58 | 0.43 | 0.41 |
RV/TLC | 0.47 | 0.58 | 0.46 | 0.56 |
T L,CO | −0.76 | −0.81 | −0.64 | −0.72 |
K CO | −0.79 | −0.77 | −0.61 | −0.62 |
FEV1: forced expiratory volume in one second
VC: vital capacity
FEF25%–75%: forced midexpiratory flows
sGaw: Specific airways conductance
TLC: total lung capacity
RV: residual volume
TL,CO: transfer factor of the lung for carbor monoxide
KCO: carbor monoxide transfer coefficient
expressed as % predicted
percentage of pixels <−910 HU
All correlations are highly significant (p<0.001)