Table 3—

Change in efficacy variables (end start of 8 weeks treatment)

VariableMorningEveningMorning – evening:
FFEV1 L0.31 (0.20–0.43)0.31 (0.19–0.43)0.00 (−0.15–0.15)
FVC L0.19 (0.06–0.33)0.22 (0.08–0.36)−0.02 (−0.19–0.14)
Morning PEF L·min−13 (−14–20)30 (13–48)−27 (−50–−5)
Evening PEF L·min−17 (−10–23)16 (0.4–32)−10 (−31–11)
Total daily symptom score−0.38 (−0.80–−0.24)−0.50 (−0.87–−0.29)0.02 (−0.29–0.43)
Daily use rescue medication, puffs 24 h−1−0.36 (−1.00–−0.29)−0.36 (−1.05–−0.21)0 (−0.43–0.43)
  • Lung function: least squares means and 95% confidence intervals (Cl)

  • symptoms and rescue medication: within groups

  • median and 95% Cl, between groups: distribution-free point estimate and 95%-Cl. FEV1: Forced expiratory volume in one second

  • FVC: Forced vital capacity

  • PEF: peak expiratory flow