Efficacy in ‘Intent to treat’ analysis of a 7-valent pneumococcal CRM197-conjugate vaccine vs control (meningococcal CRM197-conjugate vaccine) in prevention of invasive pneumococcal disease, pneumonia and otitis media
| Disease/Infectious | n | Efficacy |
| Invasive disease | ||
| Serotype-specific | 52 | 94 (80–99) |
| Regardless of serotype | 61 | 89 (74–96) |
| Pneumonia | ||
| Clinical diagnosis | 1066 | 11 (1–21) |
| Radiograph verified | 115 | 33 (7–52) |
| Consolidation | 26 | 73 (38–88) |
| Otitis media | ||
| Visits | 73041 | 8 (5–11) |
| Episodes | 52789 | 6 (4–9) |
| Frequent otitis media | 5451 | 9 (4–14) |
| Ventilatory tube placement | 432 | 20 (4–34) |
Data presented as % (95% confidence interval)
Consolidation with a diameter of ≥2 cm visible on radiograph
≥3 episodes during 6 months or ≥4 episodes during 1 yr
CI: confidence interval
Adapted from 6 and 81