Table 1—

Microvascular pressure and hydrostatic challenge-induced lung weight gain in control lungs, ischemic lungs and ischemic lungs exposed to prostaglandin E1 (PGE1) prostaglandin I2 (PGI2) or sodium nitroprusside (SNP). 1st Revision

ParadigmConditions during ischaemiaWeight gain gMicrovascular pressure mmHg
Duration minFi,O2Aerosolation time minEnd-ischaemic intravascular pressure mmHgnBefore ischemia30 min after reperfusion60 min after reperfusion90 min after reperfusionBefore ischemia3 min after reperfusion30 min after reperfusion60 min after reperfusion90 min after reperfusion
Control1800.21170(no ischemia)60.7±0.21.5±0.21.6±0.31.6±0.14.7±0.15.3±0.25.3±0.35.0±0.24.8±0.2
2100.21170(no ischemia)51.2±0.22.2±0.22.2±0.32.2±0.34.4±0.34.8±0.35.0±0.34.8±0.34.9±0.3
Ischemia180053.0±0.471.0±0.27.5±0.97.9±1.54.6±0.27.8±0.75.4±0.35.1±0.3
210052.8±0.450.7±0.3>155.2±0.67.8±1.05.1±0.3
Ischemia + SNP180053.8±0.460.5±0.21.9±0.31.6±0.11.8±0.24.5±0.25.8±0.65.5±0.34.8±0.24.8±0.2
18001703.5±0.560.7±0.12.4±0.31.9±0.45.0±0.66.3±0.65.5±0.55.2±0.3
210053.4±0.350.3±0.15.0±1.35.3±1.74.3±1.74.6±0.25.8±0.34.9±0.24.7±0.24.6±0.3
Ischemia+PGE1180054.1±0.360.9±0.22.8±0.52.4±0.52.6±0.34.5±0.26.3±0.45.5±0.34.9±0.24.6±0.2
18001702.9±0.460.6±0.17.3±1.16.9±1.44.7±0.26.5±0.65.3±0.45.0±0.2
2100053.4±0.450.6±0.25.2±0.95.6±1.54.5±1.24.9±0.27.2±0.25.8±0.35.1±0.35.7±0.4
Ischemia+PGI2180053.5±0.260.8±0.13.0±0.52.8±0.52.7±0.95.0±0.26.7±0.26.3±0.35.2±0.25.1±0.2
18001703.0±0.160.6±0.24.2±0.73.9±0.64.9±1.14.9±0.35.8±0.75.4±0.44.9±0.34.8±0.3
210053.4±0.350.6±0.26.8±2.14.5±0.34.2±0.34.7±0.26.9±0.55.8±0.34.9±0.14.7±0.0
  • Data are presented as mean±sem

  • During ischemia, lunge were ventilated with an oxygen-free gas mixture and exposed to a positive intravascular pressure

  • I,O2: inspiratory oxegen fraction

  • p<0.05 versus controls

  • p<0.01 versus all time-matched other groups