Table 2—

Values for selected variables during steady-state exercise

Parameter1 hour6 hour
SIBMean (95% CI) The difference between S and IBSIBMean (95% CI) The difference between S and IB
Work watts25±1525±15 0.0 (0.0–0.0) 25±1525±15 0.0 (−0.9–0.4)
VO2 L·min−10.65±0.230.65±0.24 0.00 (−0.05–0.05) 0.67±0.230.64±0.20 0.03 (−0.01–0.06)
HR beats·min−1101±1895±17 6.0 (1.1–10.9) 101±14101±15 0.0 (−4.8–4.8)
VE L·min−126±826±8 0.0 (−2.3–3.2) 26±824±6 2.0 (−0.5–3.1)
Tidal volume L1.18±0.351.18±0.32 0.0 (−0.09–0.08) 1.12±0.331.08±0.26 0.04 (−0.10–0.09)
IC L2.03±0.651.99±0.56 0.04 (−0.04–0.15) 1.88±0.711.76±0.55 0.12 (0.00–0.24)
EILV L6.49±1.566.47±1.56 0.02 (−0.08–0.17) 6.57±1.456.68±1.62 −0.11 (−0.16–0.26)
EELV L5.31±1.385.28±1.42 0.03 (−0.08–0.18) 5.60±1.355.62±1.53 −0.02 (−0.24–0.21)
Dyspnoea (0–10)2.0±1.31.9±1.4 0.1 (−0.6–0.8) 2.1±1.22.2±1.2 −0.1 (−0.5–0.2)
  • Values are presented as mean±sd during 5 min of steady-state exercise

  • VO2: oxygen consumption

  • HR: heart rate

  • VE: minute ventilation

  • IC: inspiratory capacity

  • EILV: end-inspiratory lung volume

  • EELV: end-expiratory lung volume

  • CI: confidence interval

  • S: salmeterol

  • IB: ipratropium bromide

  • Analysis of variance for multiple comparisons used to compare S and IB at 1 and 6 h

  • p=0.02 for S>IB at 1 h

  • p=0.03 for S>IB at 6 h

  • p=0.05 for S<IB at 6 h

  • For all other comparisons between S versus IB, p>0.05