Table 1—

Values for forced expiratory volume in one second (FEV1) and lung volumes at rest after bronchodilator therapy

1 hour6 hour
SIBMean (95% CI) diff.-valueSIBMean (95% CI) diff.-value
FEV11.36±0.50 (20)1.33±0.47 (18)0.03 (−0.07–0.13)0.531.36±0.58 (20)1.25±0.48 (11)0.11 (−0.06–0.30)0.19
FVC3.48±1.01 (16)3.55±0.91 (18)−0.07 (−0.17–0.05)0.243.46±1.09 (15)3.23±0.88 (7)0.23 (−0.02–0.47)0.07
TLC7.34±1.63 (−2)7.27±1.62 (−4)0.07 (−0.05–0.20)0.247.48±1.59 (0)7.38±1.66 (−2)0.10 (−0.05–0.25)0.17
FRC5.22±1.20 (−9)5.04±1.35 (−12)0.18 (−0.01–0.38)0.075.11±1.21(−11)5.20±1.45 (−9)−0.09 (−0.38–0.21)0.54
RV3.81±1.07 (−15)3.73±1.16 (−17)0.08 (−0.08–0.24)0.313.92±1.02 (−13)4.07±1.17 (−9)−0.15 (−0.40–0.12)0.27
IC2.12±0.56 (6)2.23±0.51 (12)−0.11 (−0.37–0.14)0.112.37±0.55 (19)2.18±0.63 (9)0.19 (−0.21–0.28)0.77
  • Data are presented as mean±sd (% change from premedication values)

  • S: salmeterol

  • IB: ipratropium bromide

  • CI: confidence interval

  • FVC: force vital capacity

  • TLC: total lung capacity

  • FRC: functional residual capacity

  • RV: residual volume

  • IC: inspiratory cppacity

  • mean differences between S and IB. The paired t-test was used to compare S and IB at 1 hr and at 6 h