Time-course of work-related symptoms and occupational diseases in apprentices exposed to laboratory animals
| Years in the programme | Incidence-density | ||||
| 1 | 2 | 3 | 4 | ||
| Number present at visit | 136 | 345 | 355 | 98 | |
| Skin reactivity | |||||
| Programme-related antigen | 14 (10.3) | 37 (10.7) | 29 (8.2) | 5 (5.1) | 85/1075 (7.9) |
| Mites | 4 (2.9) | 14 (4.1) | 14 (3.9) | 1 (1.0) | 33/716 (4.6) |
| Pets | 9 (6.6) | 7 (2.0) | 14 (3.9) | 5 (5.1) | 35/926 (3.8) |
| Pollens | 0 (0) | 8 (2.3) | 8 (2.3) | 1 (1.0) | 17/788 (2.2) |
| Work-related symptoms | |||||
| Skin | 4 (2.9) | 33 (9.6) | 39 (11.0) | 5 (5.1) | 81/1051 (7.7) |
| Rhinoconjunctivitis | 17 (12.5) | 48 (13.9) | 30 (8.5) | 4 (4.1) | 99/961 (10.3) |
| Respiratory | 1 (0.7) | 11 (3.2) | 9 (2.5) | 1 (1.0) | 22/1115 (2.0) |
| Occupational | |||||
| Rhinoconjunctivitis | 9 (6.6) | 24 (7.0) | 29 (8.2) | 0 (0) | 62/1096 (5.7) |
| Asthma | 5 (3.7) | 9 (2.6) | 13 (3.7) | 1 (1.0) | 28/1043 (2.7) |
Data presented as n (%) or incidence (%)
Total number of participants=417 except for the assessment of occupational asthma (n=373) because 44 students refused the methacholine inhalation test
number of cases/person-yrs in the programme