Table 5– Longitudinal hazard ratios (HRs) for mortality associated with absolute increases in composite physiologic index (CPI) and relative decreases in individual pulmonary function tests over 6 and 12 months in patients with combined pulmonary fibrosis and emphysema

	6-month change			12-month change
	n (%)	HR (95% CI)	p-value	n (%)	HR (95% CI)	p-value
None-to-mild empysema^#
10% decline FEV₁	31 (24.4)	1.4 (0.8–2.6)	0.268	26 (30.2)	2.5 (1.2–5.1)	0.012
10% decline FVC	36 (28.3)	1.4 (0.8–2.6)	0.209	29 (33.7)	2.8 (1.4–5.9)	0.005
15% decline D_L,CO	31 (24.4)	2.4 (1.3–4.4)	0.005	33 (38.4)	2.9 (1.4–5.7)	0.003
+5 increase CPI	33 (26.0)	2.4 (1.3–4.4)	0.003	34 (39.5)	3.6 (1.7–7.7)	0.001
Moderate-to-severe emphysema^¶
10% decline FEV₁	4 (9.5)	8.4 (1.9–37.8)	0.006	6 (18.8)	3.7 (1.0–13.7)	0.046
10% decline FVC	5 (11.9)	4.1 (1.2–14.0)	0.025	9 (28.1)	2.1 (0.8–6.0)	0.154
15% decline D_L,CO	13 (31.0)	2.1 (0.8–5.5)	0.140	12 (37.5)	2.1 (0.7–6.0)	0.174
+5 increase CPI	11 (26.2)	1.9 (0.6–5.7)	0.279	15 (46.8)	2.4 (0.8–7.9)	0.135

FEV₁: forced expiratory volume in 1 s; FVC: forced vital capacity; D_L,CO: diffusing capacity of the lung for carbon monoxide. ^#: n = 127 for 6-month change and n = 86 for 12-month change; ^¶: n = 42 for 6-month change and n = 32 for 12-month change.