Number of patients with clinically significant changes in vital signs for each treatment
| Treatment F/I dose in µg | Delivery device | Systolic blood pressure | Diastolic blood pressure | Cardiac frequency | |||
| ↓ | ↑ | ↓ | ↑ | ↓ | ↑ | ||
| Placebo | Respimat® | 1 | 1 | 4 | 1 | ||
| F/I 12.5/5 | Respimat® | 1 | 6 | 1 | |||
| F/I 25/10 | Respimat® | 1 | 2 | 1 | 7 | ||
| F/I 50/20 | Respimat® | 1 | 1 | 6 | |||
| F/I 100/40 | Respimat® | 1 | 4 | 1 | |||
| F/I 200/80 | Respimat® | 1 | 4 | 1 | |||
| F/I 50/20 | MDI | 2 | 1 | 1 | 6 | 1 | 1 |
| F/I 100/40 | MDI | 1 | 1 | 4 | |||
Arrows represent a clinically significant increase (↑) or decrease (↓) in blood pressure or cardiac frequency.