Outcomes of the simulated methacholine three-fold dose protocol for separate groups during early protocol steps
| Cumulative dose µmol | FEV1/FVCbl <0.8 (n=169) | FEV1/FVCbl ≥0.8 (n=280) | ||
| ΔFEV1 30–40% | ΔFEV1 >40% | ΔFEV1 30–40% | ΔFEV1 >40% | |
| 0.073 | 1 (0.6) | 2 (1.2) | nd | nd |
| 0.126* | 0* | 0* | nd | nd |
| 0.219 | 0 | 0 | 0 | 0 |
Data are presented as number of subjects (percentage of subjects participating at that dose) at each inhalation step, including intermediate steps (indicated by *). ΔFEV1: the percentage change in forced expiratory volume in one second from baseline; FEV1/FVCbl: baseline ratio of forced expiratory volume to forced vital capacity; nd: not determined.