TABLE 1

Overview of the different test sets evaluated

	Time intervals of ECG before PH diagnosis^#
	Mayo Clinic test set				VUMC test set
	Within 1 month	6–18 months	18–36 months	36–60 months	Within 1 month	6–18 months	18–36 months	36–60 months
Full diagnostic test set
Control patients	87 998				24 256
PH patients	16 175	4985	4784	4135	6045	1880	1602	1321
Patients with dyspnoea ICD code^¶
Control patients	16 155				9208
PH patients	7155	2187	1811	1286	3719	1147	909	678
PH patients with RHC diagnosis
mPAP >20 mmHg	2737	785	614	436	1940	564	412	296
Pc-PH	507				283
Ipc-PH	785				686
Cpc-PH	609				442
mPAP >25 mmHg	2307	670	531	378	1599	478	363	254

Data are presented as n. PH: pulmonary hypertension; VUMC: Vanderbilt University Medical Center; ICD: International Classification of Disease; RHC: right heart catheterisation; mPAP: mean pulmonary arterial pressure; Pc-PH: pre-capillary PH; Ipc-PH: isolated post-capillary PH; Cpc-PH: combined pre- and post-capillary PH. ^#: the numbers sum to greater than the total number of patients included in the study, as patients could belong to more than one time interval, e.g. if they had an ECG within 1 month of RHC and another ECG 36 months before RHC; ^¶: dyspnoea ICD code on or before an eligible ECG and the diagnostic RHC/echocardiogram (for PH patients) or the last screening RHC/echocardiogram (for control patients).