Weight bin | Weight range, kg | Dose, mg twice daily | Capsule strength, mg | Reduced dose, mg twice daily | Capsule strength for reduced dose, mg |
1 | 13.5#– <23.0 | 50 | 25 (2×) | 25 | 25 (1×) |
2 | 23.0– <33.5 | 75 | 25 (3×) | 50 | 25 (2×) |
3 | 33.5– <57.5 | 100 | 100 (1×) or 25 (4×) | 75 | 25 (3×) |
4 | ≥57.5 | 150 | 150 (1×) or 25 (6×) | 100 | 100 (1×) or 25 (4×) |
#: patients with weight <13.5 kg were excluded from the trial.