Asthma remission: future research questions
| Definition | |
| 1 | Does the definition of remission require measurement of inflammation? |
| 2 | How do asthma control and severity relate to asthma remission? |
| Treatment-induced remission | |
| 3 | Is treatment-induced remission possible? |
| 4 | How does treatment-induced remission compare with spontaneous asthma remission, based on prevalence, predictors and risk of relapse? |
| 5 | Is it possible to increase the proportion of people achieving remission with treatment? |
| 6 | Is it possible to prolong the remission period with treatment? |
| 7 | What are the rates of remission with MART and step therapy? |
| 8 | Does prolonging asthma treatment after control is achieved increase the chance of asthma remission? |
| Trajectory of remission | |
| 9 | How long should the treatment be continued to achieve remission? When to move from one stage to another? |
| Pathophysiology | |
| 10 | What are the molecular events leading to airway remodelling? |
| 11 | Can airway remodelling be treated? |
| 12 | Does treating airway remodelling induce remission? |
| Relapse | |
| 13 | How does ongoing airway inflammation and remodelling affect relapse? |
| 14 | How can inflammation/remodelling be effectively treated to prevent relapse in those who are in clinical remission? |
| Biologics and asthma remission | |
| 15 | What is the prevalence of remission after biologics therapy for asthma? |
| 16 | Are biologics more effective than inhaled preventers at achieving asthma remission? |
| 17 | Does the early introduction of biologics modify the trajectory of asthma and halt the disease progression? |
| 18 | Does continuing the treatment with biologics prolong remission and prevent relapse? |
| 19 | Is it possible to stop all asthma treatments except biologics in a patient who has achieved remission with biological therapies? |
| Macrolide therapy | |
| 20 | What is the prevalence of remission after macrolide therapy for asthma? |
| Treatable traits | |
| 21 | Does targeting treatable traits increase the chance of asthma remission? |
MART: maintenance and reliever therapy.