Baseline characteristics and previously known obstructive sleep apnoea (OSA) comorbidities between OSA and non-OSA individuals in the FinnGen cohort
| All | Non-OSA | OSA | OR (95% CI) | p-value | |
| Subjects | 217 955 | 201 194 | 16 761 | ||
| Sex | |||||
| Male | 94 799 (43.5) | 84 242 (41.9) | 10 557 (63.0) | 2.26 (2.19–2.34) | <2.00×10−16 |
| Female | 123 156 (56.5) | 116 952 (58.1) | 6204 (37.0) | ||
| Age years | 52.4±17.5 | 51.8±17.7 | 58.9±13.3 | 1.02 (1.02–1.03) | <2.00×10−16 |
| Age at OSA diagnosis years | 55.3±11.9 | ||||
| BMI kg·m−2 | 27.25±5.34 | 26.87±5.02 | 31.72±6.74 | 1.15 (1.15–1.16) | <2.00×10−16 |
| Comorbidity | |||||
| Hypertension | 55 678 (25.5) | 47 549 (23.6) | 8129 (48.5) | 2.44 (2.36–2.53) | <2.00×10−16 |
| T2D | 29 054 (13.3) | 23 932 (11.9) | 5122 (30.6) | 2.60 (2.50–2.70) | <2.00×10−16 |
| CHD | 20 925 (9.6) | 18 495 (9.2) | 2430 (14.5) | 1.11 (1.06–1.17) | 1.04×10−5 |
| Stroke | 11 671 (5.4) | 10 414 (5.2) | 1257 (7.5) | 1.10 (1.03–1.17) | 3.29×10−3 |
| Depression | 23 160 (10.6) | 20 094 (10.0) | 3066 (18.3) | 2.56 (2.45–2.67) | <2.00×10−16 |
| Hypothyroidism | 26 228 (12.0) | 23 384 (11.6) | 2844 (17.0) | 1.85 (1.77–1.94) | <2.00×10−16 |
| Asthma | 20 520 (9.4) | 17 358 (8.6) | 3162 (18.9) | 2.58 (2.47–2.69) | <2.00×10−16 |
| IRD | 12 961 (5.9) | 11 555 (5.7) | 1406 (8.4) | 1.48 (1.39–1.57) | <2.00×10−16 |
Data are presented as n, n (%) or mean±sd, unless otherwise stated. BMI: body mass index; T2D: type 2 diabetes; CHD: coronary heart disease; IRD: inflammatory rheumatic disease. Age and BMI were measured at the time when the biobank sample was given. BMI was measured in 159 731 individuals, including 12 759 OSA cases and 146 972 controls.