Impact of choice of selection methods on ability to replicate trial results for the analysis of exacerbations, in people exposed to fluticasone propionate (FP)-salmeterol (SAL) versus people exposed to SAL
| Rate ratio | Subjects per exposure group n | ||
| SAL | FP-SAL | ||
| TORCH trial | 1 | 0.88 (0.81–0.95) | 1524 |
| CPRD non-interventional selection method# | |||
| TORCH inclusion and exclusion criteria and matched to TORCH¶ | 1 | 0.85 (0.74–0.97) | 991 |
| TORCH inclusion and exclusion criteria only | 1 | 0.87 (0.81–0.94) | 3225 |
| No TORCH criteria or matching | 1 | 1.64 (1.52–1.77) | 5951 |
CPRD: Clinical Practice Research Datalink. #: SAL and FP-SAL groups were propensity score matched for all selection methods; ¶: as per the main analysis and presented in table 4.