TABLE 3

Outcomes for patient care and clinical research

	Measure	Category	Level
Pulmonary sarcoidosis	Patient wellbeing	Physician judgement	Important
	Clinical judgement of improvement, worsening/progression	Physician judgement	Critical
	Clinical judgement alone		Critical
	Treatment chest imaging: Scadding score [20], changes in	Treatment imaging	Important
	Treatment chest imaging: Muers score [49], changes in	Treatment imaging	Important
	PET/CT chest imaging, changes in	Scan	Important
	Pulmonary function tests: FVC, FEV₁, FEV₁/FVC, D_LCO, S_aO₂	Lung function tests	Critical
	6-min walk distance [50]	Exercise capacity	Important
	Quality of life	Quality of life	Important
	SGRQ [51]
	Short Form-36 [52]
	Fatigue Assessment Scale [53]
	SAT Lung [54]
	KSQ General health [55]
	KSQ Lung health [55]
	Serious AEs; life-threatening AEs	AEs	Critical
	AEs leading to discontinuation
	Other AEs
Extrapulmonary sarcoidosis	Physician global assessment	Cutaneous sarcoidosis disease activity	Important
	SASI [56]
	CSAMI [57]
	Photographs
	Clinical judgement of improvement, worsening/progression	Physician judgement	Critical
	Skin measure of disease		Important
	Eye measure of disease		Critical
	Kidney measure of disease		Important
	Löfgren syndrome measure of disease
	Hypercalcaemia		Critical
	Quality of life	Quality of life	Critical
	Fatigue Assessment Scale
	SAT Skin [54]
	SAT Fatigue [54]
	KSQ Dermatology questionnaire
	Serious AEs; life-threatening AEs	AEs	Critical
	AEs leading to discontinuation
	Other AEs
Cardiac sarcoidosis	Clinical judgement of improvement, worsening/progression	Physician judgement	Critical
	PET/CT chest imaging, changes in	Treatment imaging	Critical
	MRI chest imaging, changes in	Treatment imaging
	Arrythmias	Arrythmias	Critical
	Quality of life	Quality of life	Important
	Serious AEs; life-threatening AEs	AEs	Critical
	AEs leading to discontinuation
	Other AEs
Neurosarcoidosis	Measures of neurologic disease	Physician judgement	Critical
	Clinical judgement of improvement, worsening/progression	Physician judgement
	Quality of life	Quality of life	Critical
	Serious AE; life-threatening AEs	AEs	Critical
	AEs leading to discontinuation
	Other AEs
All categories	Steroid sparing	Steroid sparing	Critical

PET: positron emission tomography; CT: computed tomography; FVC: forced vital capacity; FEV₁: forced expiratory volume in 1 s; D_LCO: diffusing capacity of the lung for carbon monoxide; S_aO₂: arterial oxygen saturation; SGRQ: St George's Respiratory Questionnaire; SAT: Sarcoidosis Assessment Tool; KSQ: King's Sarcoidosis Questionnaire; AE: adverse event; SASI: Sarcoidosis Activity and Severity Instrument; CSAMI: Cutaneous Sarcoidosis Activity and Morphology Instrument; MRI: magnetic resonance imaging.