Patient cohort characteristics at baseline
| Patients | 165 |
| Female | 94 (57.0) |
| Age years median (range) | 61 (18–83) |
| Former or current smoker | 69 (41.8) |
| GAP index+ | |
| Stage I | 81 (64.3) |
| Stage II | 39 (31.0) |
| Stage III | 6 (4.8) |
| UIP-like fibrotic pattern on HRCT | 46 (27.9) |
| Criteria for disease progression in previous 24 months | |
| Relative FVC decline of ≥10% pred | 109 (66.1) |
| Relative FVC decline of 5–<10% pred plus worsening of respiratory symptoms or increased extent of fibrosis on HRCT | 41 (24.8) |
| Worsening of respiratory symptoms and increased extent of fibrosis on HRCT | 15 (9.1) |
| FVC | |
| Volume mL# | 2333±935 |
| % predicted¶ | 74±22 |
| DLCO# % predicted | 44±18 |
| Time from diagnosis to first meeting criteria for progression# years mean (IQR) | 2.0 (0–3.3) |
Data are presented as n, n (%) or mean±sd, unless otherwise stated. GAP: Gender, Age and Physiology; UIP: usual interstitial pneumonia; HRCT: high-resolution computed tomography; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; IQR: interquartile range. +: n=126; #: n=135; ¶: n=138.