Complete clinical multivariable model for severe/critical disease

OR (95% CI)p-value*
DLCO, 10%-pred.0.59 (0.37–0.87)0.01
Age, year0.98 (0.92–1.05)0.62
Sex, men1.98 (0.50–8.56)0.34
BMI, kg/m21.19 (1.03–1.41)0.02
6MWD, 10 m0.88 (0.67–0.95)0.01
Min. SpO2, %0.80 (0.44–0.95)0.07

Effect estimates indicate the associations of the variables with severe/critical disease in the context of the complete multivariable model. E.g. for every 10 meters increase in 6MWD the odds for severe/critical disease decreases by 12% adjusting for age, sex, BMI, DLCO, and minimal SpO2. The overall area under the receiver operating curve (AUC) of the multivariable model including DLCO, age, sex, BMI, 6MWD, and minimal SpO2 was 0.95 (95% CI 0.88–1.00).

Abbreviations: AUC: area under the receiver operating curve; BMI: body mass index; CI: confidence interval; DLCO: diffusing capacity of the lung for carbon monoxide; OR: odds ratio; 6MWD: 6-min walk distance; min. SpO2: minimal oxygen saturation on 6-min walk test.