TABLE 1

Characteristics of 22 patients co-infected with active/treated tuberculosis (TB) and coronavirus disease 2019 (COVID-19)

PatientAge years/genderTB statusSite of TBATT historyClinical presentation on admissionComorbiditiesSpO2 %, respiratory rate per min, GCS, qSOFALaboratory findingsFindings in chest radiograph prior to COVID-19Bilateral new infiltrates, consistent with COVID-19, on CXRRequired critical care, required IMVDuration of hospital stay daysEndpoint attained (discharged/died)
154/MaleTreatedPTBCompleted DS-TB regimen 2 years earlierFever for 2 daysHypertension, hypothyroidismSpO2 98,
RR 19,
GCS 15,
qSOFA 0
TLC 4800 (48% lymphocytes)Right lung fibrosisYesNo15Discharged
258/MaleTreatedPTBCompleted DS-TB regimen 1 year earlierFever for 5 daysSpO2 95,
RR 24,
GCS 15,
qSOFA 1
TLC 8500 (40% lymphocytes)Right lung fibrosisYesNo7Discharged
344/MaleTreatedPTBCompleted DS-TB regimen 2 years earlierFever for 6 daysSpO2 98,
RR 20,
GCS 15,
qSOFA 0
TLC 4100 (31% lymphocytes)Left lung fibrosisNoNo15Discharged
419/MaleTreatedPTBCompleted DS-TB regimen 1 year earlierAsymptomaticSpO2 95,
RR 18,
GCS 15,
qSOFA 0
TLC 4400 (45% lymphocytes)Left lung fibrosisNoNo15Discharged
526/MaleTreatedPTBCompleted DS-TB regimen 2 years earlierFever and cough 3 daysSpO2 95,
RR 18,
GCS 15,
qSOFA 0
TLC 5300 (30% lymphocytes)Right lung fibrosisNoNo5Discharged
648/MaleTreatedPTBCompleted DS-TB regimen 1 year earlierBreathlessness for 2 days, fever and cough for 2 weeksDiabetes mellitusSpO2 80,
RR 38,
GCS 4,
qSOFA 3
TLC 8200 (42% lymphocytes)Left lung fibrosis and left upper zone cavityYesRequired critical care and IMV<1Died
730/MaleTreatedPTBCompleted DS-TB regimen 2 months earlierFever for 3 daysSpO2 99,
RR 20,
GCS 15,
qSOFA 0
TLC 7700 (42% lymphocytes)Right lung fibrosis and right upper zone cavitationNoNo16Discharged
838/MaleTreatedPTBCompleted DS-TB regimen 6 years earlierFever, cough and breathlessness for 5 daysSpO2 81,
RR 38,
GCS 3,
qSOFA 3
Left lung fibrosisYesRequired critical care and IMV<1Died
945/MaleTreatedPTBCompleted DS-TB regimen 6 months earlierBreathlessness for 2 days, fever for 5 days, cough for 1 monthSpO2 78,
RR 32,
GCS 3,
qSOFA 3
ABGA, respiratory acidosisLeft lung fibrosis and upper and mid zone cavitationYesRequired critical care and IMV<1Died
1045/MaleActivePTBOn DS-TB regimen for 1 monthFever, headache, cough, breathlessness for 3 daysSpO2 86,
RR 32,
GCS 3,
qSOFA 2
Hb 10.4, TLC 15 000 (10% lymphocytes), Plt 180 000, blood urea 125, creatinine 6.5, total bilirubin 0.5, AST 456, ALT 178Left upper zone cavitationYesRequired critical care and IMV2Died
1126/MaleActivePTBOn DS-TB regimen for 3 monthsFever for 2 daysSpO2 94,
RR 20,
GCS 15,
qSOFA 0
TLC 8000 (20% lymphocytes)Right upper zone infiltratesNoNo20Discharged
1263/MaleActivePTBOn DS-TB regimen for 2 monthsBreathlessness for 5 days, fever for 12 daysSpO2 92,
RR 24,
GCS 15,
qSOFA 1
TLC 9000 (40% lymphocytes)Right upper zone cavitationYesNo24Discharged
1329/MaleActivePTBOn DS-TB regimen for 1 monthFever for 2 daysSpO2 98,
RR 16,
GCS 15,
qSOFA 0
TLC 8500 (30% lymphocytes)Left mid zone consolidationNoNo15Discharged
1465/FemaleActivePTBOn MDR-TB regimen for 1 yearFever, cough and breathlessness for 5 daysDiabetes mellitus, hypertensionSpO2 76,
RR 34,
GCS 4,
qSOFA 3
ABGA, high anion gap metabolic acidosis, diabetic ketoacidosis with blood sugar value of 470 mg·dL−1), blood urea 70, creatinine 3.8, TLC 17 300 (22% lymphocytes)Right upper, mid and lower zone consolidationYesRequired critical care and IMV1Died
1529/MaleActiveEPTB (CNS-TB)On ATT for CNS-TB for 12 monthsFever and cough for 1 month with weight lossSeizure disorderSpO2 90,
RR 24,
GCS 15,
qSOFA 1
TLC 800 (26% lymphocytes)YesRequired critical care but not IMV#20Discharged
1626/MaleActivePTBOn DS-TB regimen for 4 monthsFever and cough for 2 daysSpO2 95,
RR 20,
GCS 15,
qSOFA 0
TLC 8100 (40% lymphocytes)Right upper zone infiltratesYesNo8Discharged
1756/MaleActivePTBOn DS-TB regimen for 3 monthsFever and cough for 3 daysHypertensionSpO2 93,
RR 18,
GCS 15,
qSOFA 0
TLC- 9700 (36% Lymphocytes)Left upper zone infiltratesYesNo7Discharged
1836/MaleActiveDisseminated TB (pulmonary and abdominal)On DS-TB regimen for 2 monthsFever for 2 daysSpO2 98,
RR 18,
GCS 15,
qSOFA 0
TLC 7900 (47% lymphocytes)Left upper zone cavitationYesNo10Discharged
1940/MaleActive and newly diagnosed concommitantly with COVID-19EPTB (pleural effusion)Initiated on DS-TB regimenFever and cough for 2 daysSpO2 99,
RR 16,
GCS 15,
qSOFA 0
TLC 8300 (39% lymphocytes)Left pleural effusionNoNo10Discharged
2021/MaleActiveEPTB (cervical LN-TB)On DS-TB regimen for 1 monthFever for 2 daysSpO2 75,
RR 36,
GCS 4,
qSOFA 1
ABGA, high anion gap metabolic acidosis, blood urea 72, creatinine 3.8, TLC 19 600 (27% lymphocytes)YesRequired critical care and IMV5Died
2128/FemaleActivePTBOn DS-TB regimen for 1 monthFever for 2 daysSpO2 95,
RR 18,
GCS 15,
qSOFA 0
TLC 6300 (32% lymphocytes)Left upper zone infiltratesNoNo12Discharged
2267/MaleActiveEPTB (pleural effusion)On DS-TB regimen for 2 monthsFever, cough and breathlessness for 3 daysDiabetes mellitus, hypertension, seizure disorderSpO2 95,
RR 20,
GCS 15,
qSOFA 0
TLC 3700 (34% lymphocytes)Right pleural effusionYesNo14Discharged

PTB: pulmonary tuberculosis; EPTB: extra-pulmonary tuberculosis; CNS-TB: central nervous system tuberculosis; LN-TB: lymph node tuberculosis; ATT: anti-tubercular treatment; DS-TB: drug sensitive tuberculosis; MDR-TB: multi-drug resistant tuberculosis; SpO2: oxygen saturation by pulse oximetry; GCS: Glasgow coma scale score; qSOFA: quick sepsis related organ failure score; TLC: total leukocyte count (unit: per mm3); ABGA: arterial blood gas analysis; Hb: haemoglobin (unit: g·dL−1); Plt: platelet count (unit: per mm3), AST: aspartate transaminase (unit: IU·L−1); ALT: alanine transaminase (unit: IU·L−1); CXR: chest radiograph; IMV: invasive mechanical ventilation. Laboratory parameters for blood urea, creatinine and bilirubin are provided in units of mg·dL−1. #: patient's duration of stay in intensive care unit was 5 days, and on ward was 15 days.