TABLE 1

The comparison of different clinical prediction rules

VariableAUC (95% CI)p-valueCut-off valueSensitivity (95% CI)Specificity (95% CI)PPV (95% CI)NPV (95% CI)NRIIDI
A-DROP0.87 (0.84–0.90)Ref20.80 (0.73–0.87)0.86 (0.83–0.89)0.60 (0.52–0.67)0.94 (0.92–0.96)RefRef
CURB-650.85 (0.81–0.89)0.225920.63 (0.55–0.71)0.91 (0.89–0.93)0.65 (0.56–0.73)0.91 (0.88–0.93)0.120.06
PSI0.85 (0.81–0.88)0.187630.77 (0.70–0.84)0.81 (0.78–0.84)0.50 (0.44–0.57)0.93 (0.91–0.96)0.080.07
SMART-COP0.84 (0.80–0.88)0.040520.83 (0.77–0.89)0.76 (0.72–0.80)0.46 (0.40–0.53)0.94 (0.92–0.97)0.080.11
NEWS20.81 (0.77–0.85)0.004550.79 (0.72–0.86)0.69 (0.65–0.73)0.40 (0.34–0.46)0.93 (0.90–0.95)0.170.16
CRB-650.80 (0.76–0.84)0.000110.83 (0.77–0.89)0.69 (0.65–0.73)0.40 (0.34–0.46)0.94 (0.92–0.96)0.150.15
qSOFA0.73 (0.69–0.78)<0.000110.82 (0.75–0.89)0.57 (0.53–0.61)0.33 (0.28–0.38)0.93 (0.90–0.95)0.270.24

AUC: area under the curve; PPV: positive predictive value; NPV: negative predictive value; NRI: net reclassification improvement; IDI: integrated discrimination improvement; C(U)RB-65: confusion, (urea >7 mmol·L−1), respiratory rate ≥30 breaths·min−1, blood pressure <90 mmHg (systolic) ≤60 mmHg (diastolic), age ≥65 years; PSI: pneumonia severity index; NEWS2: national early warning score 2; qSOFA: quick sequential organ failure assessment.