TABLE 1

Estimated prevalence of PI*SZ and PI*ZZ genotypes from registries

SubjectsGenotype
PI*SZPI*ZZ
ADAPT: The UK Registry [15]1203135 (11.2)930 (77.3)
AlphaNet (USA) [16, 17]5523504 (9.13)3031 (54.9)
Italian Registry [18]42274 (17.5)258 (61.1)
German Registry [20]1066109 (10.2)820 (76.9)
Spanish Registry [21]469#100 (21.3)348 (74.2)
AIR [19, 41]4758538 (11.3)4031 (84.7)
Alpha One Foundation (Ireland) [25]5520275 (4.9)305 (5.5)
NHLBI [22]102110 (1.0)993 (97.3)
AOF-RNR [23]71215 (2.1)503 (70.7)

Data are presented as n or n (%). ADAPT: Antitrypsin Deficiency Assessment and Programme for Treatment; AIR: Alpha One International Registry; NHLBI: National Heart, Lung, and Blood Institute; AOF-RNR: Alpha One Foundation Research Network Registry. #: only adult patients included; : excluding PI*MM individuals.