Clinical characteristics of children enrolled in AREST CF for which computed tomography scans were available
| 1–2 years | 3–4 years | 5–6 years | |
| Age years | 1.66±0.20 | 3.68±0.21 | 5.66±0.21 |
| Males | 70/139 (50.36) | 81/162 (50.00) | 82/167 (49.10) |
| Test centre Perth/Melbourne | 72/139 (51.80) | 79/162 (48.77) | 67/167 (40.12) |
| Genotype | |||
| Homozygous Phe508del/Phe508del | 71/139 (51.08) | 85/158 (53.80) | 83/161 (51.55) |
| Heterozygous Phe508del/other | 64/139 (46.04) | 68/158 (43.04) | 71/161 (44.10) |
| Meconium ileus | 27/134 (20.15) | 30/156 (19.23) | 31/158 (19.62) |
| Pancreatic sufficient | 20/139 (14.39) | 25/162 (15.43) | 25/164 (15.24) |
| PSA culture positive | 14/139 (10.07) | 20/162 (12.35) | 22/167 (13.17) |
| Structural lung disease | |||
| Bronchiectasis presence | 46/139 (33.09) | 98/162 (60.49) | 123/167 (73.65) |
| Trapped air presence | 106/139 (76.26) | 99/162 (61.11) | 127/167 (76.05) |
| Mucus plugging presence | 11/139 (7.91) | 44/162 (27.16) | 62/167 (37.13) |
| Bronchial wall thickening presence | 106/139 (76.26) | 142/162 (87.65) | 154/167 (92.22) |
| Spirometry measured lung function at age 5–6 years | |||
| FEV1 Z-score | −0.06±1.19 | −0.08±1.24 | −0.10±1.24 |
| FVC Z-score | 0.57±1.18 | 0.57±1.22 | 0.65±1.19 |
| FEV1/FVC Z-score | −0.70±0.98 | −0.70±1.01 | −0.75±0.99 |
| FEF25–75 Z-score | −0.35±1.17 | −0.33±1.18 | −0.34±1.18 |
Data are presented as n/N (%) or mean±sd. Scans were divided into age groups, with only a single scan per child in each age group. There are multiple scans of the same child in different age groups. PSA: Pseudomonas aeruginosa; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity: FEF25–75: forced expiratory flow at 25–75% of FVC.