Comparison of clinical features of patients with SARS-CoV-2 infection who treated with Lopinavir/Ritonavir and without Lopinavir/Ritonavir in Wuhan
| Variable | LPV/r group (n=78) | No LPV/r group (n=42) | P value |
| Age, Y | 50 (34–61) | 57 (36.5–66) | 0.11 |
| Male sex | 35 (44.9) | 19 (45.2) | 0.83 |
| Current smoker | 8 (10.3) | 4 (9.5) | 0.74 |
| Comorbidity | |||
| Hypertension | 19 (24.4) | 13 (31.0) | 0.39 |
| Diabetes | 8 (10.3) | 2 (4.8) | 0.49 |
| Cardiac disease# | 5 (6.4) | 2 (4.8) | 1.00 |
| Stroke | 2 (2.6) | 1 (2.4) | 1.00 |
| COPD or asthma | 1 (1.3) | 1 (2.4) | 0.34 |
| Chronic renal insufficiency | 1 (1.3) | 0 (0) | … |
| Malignancy | 4 (5.1) | 3 (7.1) | 0.69 |
| Disease severity | 0.02 | ||
| General | 53 (67.9) | 36 (85.7) | |
| Severe | 25 (32.1) | 5 (11.9) | |
| Critical | 0 (0) | 1 (2.4) | |
| Laboratory finding on admission | |||
| White blood cell count,×109 cells/L | 0.32 | ||
| <4 | 22 (28.2) | 5 (11.9) | |
| 4–10 | 49 (62.8) | 33 (78.6) | |
| >10 | 7 (9.0) | 3 (7.1) | |
| Lymphocyte count,×109 lymphocytes/L | |||
| <0.8 | 25 (32.6) | 4 (9.5) | 0.01 |
| Platelet count,×109 platelets/L | |||
| <100 | 6 (7.7) | 1 (2.4) | 0.42 |
| Creatinine level, μmol·L−1 | |||
| >133 | 1 (1.3) | 3 (7.1) | 0.11 |
| AST level, U/L | |||
| >40 | 21 (26.9) | 12 (28.6) | 0.87 |
| Treatment | |||
| Corticosteroid therapy | 44 (56.4) | 10 (23.8) | 0.001 |
| Antibiotics | 73 (93.6) | 30 (71.4) | 0.001 |
| High-flow nasal canula oxygen therapy | 17 (21.8) | 4 (9.5) | 0.13 |
| No-invasive mechanical ventilation | 1 (1.3) | 1 (2.4) | 1.00 |
| Invasive mechanical ventilation | 1 (1.3) | 0 (0) | 1.00 |
| Outcome | |||
| Viral shedding duration, d | 22 (18–29) | 28.5 (19.5–38) | 0.02 |
| Hospital length of stay, d | 23 (19–27) | 18.5 (13–22.5) | <0.01 |
Data presented as n (%) or median (IQR) unless otherwise noted.
Abbreviations: AST: aspartate aminotransferase; COPD: chronic obstructive pulmonary disease; d: day; IQR: interquartile range; y: year.
#Includes congestive heart disease and coronary atherosclerotic heart disease.