TABLE 3

Demographics and clinical characteristics of patients stratified by different comorbidities

COPDDiabetesHypertensionCardiovascular diseaseCerebrovascular disease
No (n=1566)Yes (n=24)No (n=1460)Yes (n=130)No (n=1321)Yes (n=269)No (n=1531)Yes (n=59)No (n=1560)Yes (n=30)
Age (year)48.5±16.074.7±6.847.8±16.161.2±13.446.2±15.662.1±12.548.2±15.966.3±15.148.5±16.170.4±8.9
Incubation period (day)3.6±4.24.5±3.23.6±4.13.8±5.03.6±4.23.6±4.13.7±4.23.3±3.73.6±4.23.8±3.4
Temperature on admission (℃)37.4±0.937.3±0.937.4±0.937.2±1.037.4±0.937.2±0.937.4±0.937.3±137.4±0.936.9±0.8
Respiratory rate on admission (breath·min−1)21.2±12.121.8±5.221.2±12.421.4±5.421.2±13.121.3±4.521.2±12.221.4±6.221.3±12.119.9±3.3
Heart rate (bit·minute−1)88.6±14.690.2±12.888.6±14.689.1±14.388.6±14.789±14.388.8±14.686.4±14.988.8±14.684.5±11.4
Systolic pressure on admission (mmHg)126±16.4131±17.5125.3±15.9134.4±19.1123.9±15.2135.4±18.2125.8±16.3132.3±18.8125.9±16.4132.9±16
Diastolic pressure on admission (mmHg)79.6±25.777±11.979.4±26.480.9±13.279.2±27.781±12.579.6±25.978.4±13.679.6±25.877.4±9.6
Highest temperature (℃)38.3±1.638.5±0.638.3±1.738.4±0.838.3±1.338.2±2.738.3±1.738.5±0.838.3±1.638.2±1
Sex
 Male884/1554 (56.9)20/24 (83.3)828/1449 (57.1)76/129 (58.9)748/1312 (57)156/266 (58.6)868/1520 (57.1)36/58 (62.1)881/1548 (56.9)23/30 (76.7)
 Female670/1554 (43.1)4/24 (16.7)621/1449 (42.9)53/129 (41.1)564/1312 (43)110/266 (41.4)652/1520 (42.9)22/58 (37.9)667/1548 (43.1)7/30 (23.3)
Smoking status
 Never/unknown1458/1566 (93.1)21/24 (87.5)1368/1460 (93.7)111/130 (85.4)1232/1321 (93.3)247/269 (91.8)1426/1531 (93.1)53/59 (89.8)1453/1560 (93.1)26/30 (86.7)
 Former/current108/1566 (6.9)3/24 (12.5)92/1460 (6.3)19/130 (14.6)89/1321 (6.7)22/269 (8.2)105/1531 (6.9)6/59 (10.2)107/1560 (6.9)4/30 (13.3)
Symptoms
 Fever1331/1513 (88)20/23 (87.0)1239/1412 (87.7)112/124 (90.3)1113/1273 (87.4)238/263 (90.5)1308/1482 (88.3)43/54 (79.6)1328/1507 (88.1)23/29 (79.3)
 Conjunctival congestion10/1325 (0.8)0/20 (0)9/1237 (0.7)1/108 (0.9)9/1120 (0.8)1/225 (0.4)10/1299 (0.8)0/46 (0)10/1320 (0.8)0/25 (0)
 Nasal congestion72/1281 (5.6)1/18 (5.6)66/1195 (5.5)7/104 (6.7)62/1079 (5.7)11/220 (5)67/1253 (5.3)6/46 (13.0)73/1275 (5.7)0/24 (0)
 Headache202/1309 (15.4)3/19 (15.8)187/1225 (15.3)18/103 (17.5)166/1106 (15)39/222 (17.6)197/1283 (15.4)8/45 (17.8)197/1303 (15.1)8/25 (32.0)
 Dry cough1038/1474 (70.4)14/24 (58.3)972/1378 (70.5)80/120 (66.7)854/1238 (69)198/260 (76.2)1018/1442 (70.6)34/56 (60.7)1035/1469 (70.5)17/29 (58.6)
 Pharyngodynia189/1300 (14.5)5/17 (29.4)182/1219 (14.9)12/98 (12.2)165/1102 (15)29/215 (13.5)185/1272 (14.5)9/45 (20)192/1296 (14.8)2/21 (9.5)
 Productive cough502/1400 (35.9)11/24 (45.8)462/1309 (35.3)51/115 (44.3)403/1178 (34.2)110/246 (44.7)499/1373 (36.3)14/51 (27.5)504/1397 (36.1)9/27 (33.3)
 Fatigue573/1347 (42.5)11/18 (61.1)529/1257 (42.1)55/108 (50.9)488/1143 (42.7)96/222 (43.2)564/1318 (42.8)20/47 (42.6)574/1344 (42.7)10/21 (47.6)
 Hemoptysis15/1296 (1.2)1/19 (5.3)12/1214 (1.0)4/101 (4.0)12/1096 (1.1)4/219 (1.8)15/1268 (1.2)1/47 (2.1)16/1292 (1.2)0/23 (0)
 Shortness of breath316/1371 (23)15/23 (65.2)277/1279 (21.7)54/115 (47.0)223/1154 (19.3)108/240 (45)310/1342 (23.1)21/52 (40.4)319/1366 (23.4)12/28 (42.9)
 Nausea/vomiting77/1350 (5.7)3/21 (14.3)69/1264 (5.5)11/107 (10.3)55/1134 (4.9)25/237 (10.5)73/1321 (5.5)7/50 (14.0)79/1348 (5.9)1/23 (4.3)
 Diarrhea57/1338 (4.3)0/21 (0)48/1255 (3.8)9/104 (8.7)46/1129 (4.1)11/230 (4.8)53/1313 (4.0)4/46 (8.7)57/1336 (4.3)0/23 (0)
 Myalgia/arthralgia231/1320 (17.5)3/18 (16.7)218/1234 (17.7)16/104 (15.4)188/1112 (16.9)46/226 (20.4)227/1294 (17.5)7/44 (15.9)233/1317 (17.7)1/21 (4.8)
 Chill159/1313 (12.1)4/20 (20.0)151/1230 (12.3)12/103 (11.7)140/1111 (12.6)23/222 (10.4)161/1290 (12.5)2/43 (4.7)162/1310 (12.4)1/23 (4.3)
Signs
 Throat congestion21/1269 (1.7)0/17 (0)20/1189 (1.7)1/97 (1)18/1075 (1.7)3/211 (1.4)21/1245 (1.7)0/41 (0)21/1266 (1.7)0/20 (0)
 Tonsil swelling31/1355 (2.3)0/21 (0)28/1265 (2.2)3/111 (2.7)25/1133 (2.2)6/243 (2.5)29/1326 (2.2)2/50 (4.0)31/1348 (2.3)0/28 (0)
 Enlargement of lymph nodes2/1355 (0.1)0/20 (0)2/1267 (0.2)0/108 (0)2/1135 (0.2)0/240 (0)1/1325 (0.1)1/50 (2.0)2/1347 (0.1)0/28 (0)
 Rash3/1357 (0.2)0/21 (0)2/1270 (0.2)1/108 (0.9)2/1141 (0.2)1/237 (0.4)3/1327 (0.2)0/51 (0)3/1351 (0.2)0/27 (0)
 Unconsciousness18/1400 (1.3)2/21 (9.5)18/1309 (1.4)2/112 (1.8)12/1175 (1.0)8/246 (3.3)17/1371 (1.2)3/50 (6)19/1392 (1.4)1/29 (3.4)
Abnormal chest image
 Radiograph236/1566 (15.1)7/24 (29.2)218/1460 (14.9)25/130 (19.2)178/1321 (13.5)65/269 (24.2)231/1531 (15.1)12/59 (20.3)231/1560 (14.8)12/30 (40)
 Computed tomography1113/1566 (71.1)17/24 (70.8)1034/1460 (70.8)96/130 (73.8)926/1321 (70.1)204/269 (75.8)1090/1531 (71.2)40/59 (67.8)1111/1560 (71.2)19/30 (63.3)
Hubei
 Yes633/1566 (40.4)14/24 (58.3)568/1460 (38.9)79/130 (60.8)491/1321 (37.2)156/269 (58)609/1531 (39.8)38/59 (64.4)623/1560 (39.9)24/30 (80.0)
 No933/1566 (59.6)10/24 (41.7)892/1460 (61.1)51/130 (39.2)830/1321 (62.8)113/269 (42)922/1531 (60.2)21/59 (35.6)937/1560 (60.1)6/30 (20.0)
Wuhan-contacted
 Yes1312/1566 (83.8)22/24 (91.7)1216/1460 (83.3)118/130 (90.8)1092/1321 (82.7)242/269 (90)1282/1531 (83.7)52/59 (88.1)1306/1560 (83.7)28/30 (93.3)
 No254/1566 (16.2)2/24 (8.3)244/1460 (16.7)12/130 (9.2)229/1321 (17.3)27/269 (10)249/1531 (16.3)7/59 (11.9)254/1560 (16.3)2/30 (6.7)
Severity239/1566 (15.3)15/24 (62.5)209/1460 (14.3)45/130 (34.6)166/1321 (12.6)88/269 (32.7)234/1531 (15.3)20/59 (33.9)239/1560 (15.3)15/30 (50)
Composite endpoint119/1566 (7.6)12/24 (50.0)100/1460 (6.8)31/130 (23.8)78/1321 (5.9)53/269 (19.7)118/1531 (7.7)13/59 (22.0)121/1560 (7.8)10/30 (33.3)
Deaths44/1566 (2.8)6/24 (25.0)37/1460 (2.5)13/130 (10.0)22/1321 (1.7)28/269 (10.4)42/1531 (2.7)8/59 (13.6)44/1560 (2.8)6/30 (20)
Admission to ICU92/1566 (5.9)7/24 (29.2)80/1460 (5.5)19/130 (14.6)61/1321 (4.6)38/269 (14.1)91/1531 (5.9)8/59 (13.6)92/1560 (5.9)7/30 (23.3)
Invasive ventilation45/1566 (2.9)5/24 (20.8)39/1460 (2.7)11/130 (8.5)28/1321 (2.1)22/269 (8.2)44/1531 (2.9)6/59 (10.2)46/1560 (2.9)4/30 (13.3)
Hepatitis B infectionMalignancyChronic kidney diseaseImmunodeficiency
No (n=1566)Yes (n=24)No (n=1460)Yes (n=130)No (n=1321)Yes (n=269)No (n=1531)Yes (n=59)
Age (year)48.9±16.350.8±14.848.7±16.263.1±12.148.8±16.263.7±1448.9±16.351±21.7
Incubation period (day)3.7±4.23±2.83.7±4.23.1±3.13.6±4.13.3±7.53.6±4.112.7±16.3
Temperature on admission (℃)37.4±0.937.3±0.837.4±0.937.3±0.937.4±0.937.2±137.4±0.936.6±0.2
Respiratory rate on admission (breath·min−1)21.2±12.121.2±321.3±12.120.2±1.621.3±12.119±2.821.3±1219±1
Heart rate (bit·minute−1)88.7±14.686.3±13.288.7±14.689.4±13.188.7±14.689.1±12.588.7±14.691±18.5
Systolic pressure on admission (mmHg)126.1±16.4124.8±14.7126±16.4128.3±14.5125.9±16.3135.4±20.5126.1±16.4127.3±7.4
Diastolic pressure on admission (mmHg)79.6±25.778.3±1379.5±25.781.2±8.879.5±25.779.8±1479.5±25.684.7±15
Highest temperature (℃)38.3±1.537.6±4.438.3±1.638.5±0.938.3±1.638.5±0.538.3±1.638±0.5
Sex
 Male885/1550 (57.1)19/28 (67.9)893/1560 (57.2)11/18 (61.1)891/1559 (57.2)13/19 (68.4)904/1575 (57.4)0/3 (0)
 Female665/1550 (42.9)9/28 (32.1)667/1560 (42.8)7/18 (38.9)668/1559 (42.8)6/19 (31.6)671/1575 (42.6)3/3 (100)
Smoking status
 Never/unknown1454/1562 (93.1)25/28 (89.3)1465/1572 (93.2)14/18 (77.8)1459/1569 (93)20/21 (95.2)1477/1587 (93.1)2/3 (66.7)
 Former/current108/1562 (6.9)3/28 (10.7)107/1572 (6.8)4/18 (22.2)110/1569 (7)1/21 (4.8)110/1587 (6.9)1/3 (33.3)
Symptoms
 Fever1326/1508 (87.9)25/28 (89.3)1335/1519 (87.9)16/17 (94.1)1334/1516 (88)17/20 (85)1348/1533 (87.9)3/3 (100)
 Conjunctival congestion9/1323 (0.7)1/22 (4.5)10/1330 (0.8)0/15 (0)10/1328 (0.8)0/17 (0)10/1343 (0.7)0/2 (0)
 Nasal congestion73/1277 (5.7)0/22 (0)71/1285 (5.5)2/14 (14.3)73/1282 (5.7)0/17 (0)73/1297 (5.6)0/2 (0)
 Headache202/1306 (15.5)3/22 (13.6)203/1314 (15.4)2/14 (14.3)203/1311 (15.5)2/17 (11.8)205/1326 (15.5)0/2 (0)
 Dry cough1037/1472 (70.4)15/26 (57.7)1039/1481 (70.2)13/17 (76.5)1037/1479 (70.1)15/19 (78.9)1050/1495 (70.2)2/3 (66.7)
 Pharyngodynia188/1294 (14.5)6/23 (26.1)193/1303 (14.8)1/14 (7.1)191/1300 (14.7)3/17 (17.6)193/1315 (14.7)1/2 (50)
 Productive cough508/1401 (36.3)5/23 (21.7)504/1408 (35.8)9/16 (56.3)505/1407 (35.9)8/17 (47.1)512/1421 (36)1/3 (33.3)
 Fatigue570/1340 (42.5)14/25 (56)577/1349 (42.8)7/16 (43.8)581/1350 (43)3/15 (20)583/1363 (42.8)1/2 (50)
 Hemoptysis16/1293 (1.2)0/22 (0)15/1299 (1.2)1/16 (6.3)16/1300 (1.2)0/15 (0)16/1313 (1.2)0/2 (0)
 Shortness of breath321/1370 (23.4)10/24 (41.7)323/1377 (23.5)8/17 (47.1)321/1375 (23.3)10/19 (52.6)330/1392 (23.7)1/2 (50)
 Nausea/vomiting78/1349 (5.8)2/22 (9.1)78/1355 (5.8)2/16 (12.5)79/1351 (5.8)1/20 (5)80/1369 (5.8)0/2 (0)
 Diarrhea55/1337 (4.1)2/22 (9.1)57/1343 (4.2)0/16 (0)56/1339 (4.2)1/20 (5)56/1356 (4.1)1/3 (33.3)
 Myalgia/arthralgia232/1316 (17.6)2/22 (9.1)231/1322 (17.5)3/16 (18.8)233/1323 (17.6)1/15 (6.7)233/1336 (17.4)1/2 (50)
 Chill161/1310 (12.3)2/23 (8.7)162/1318 (12.3)1/15 (6.7)161/1317 (12.2)2/16 (12.5)163/1331 (12.2)0/2 (0)
Signs
 Throat congestion21/1264 (1.7)0/22 (0)20/1271 (1.6)1/15 (6.7)21/1271 (1.7)0/15 (0)20/1284 (1.6)1/2 (50)
 Tonsil swelling30/1353 (2.2)1/23 (4.3)30/1359 (2.2)1/17 (5.9)30/1356 (2.2)1/20 (5)31/1373 (2.3)0/3 (0)
 Enlargement of lymph nodes2/1352 (0.1)0/23 (0)2/1359 (0.1)0/16 (0)2/1355 (0.1)0/20 (0)2/1372 (0.1)0/3 (0)
 Rash3/1355 (0.2)0/23 (0)3/1361 (0.2)0/17 (0)3/1360 (0.2)0/18 (0)3/1376 (0.2)0/2 (0)
 Unconsciousness19/1397 (1.4)1/24 (4.2)20/1404 (1.4)0/17 (0)20/1401 (1.4)0/20 (0)20/1418 (1.4)0/3 (0)
Abnormal chest image
 Radiograph240/1562 (15.4)3/28 (10.7)239/1572 (15.2)4/18 (22.2)240/1569 (15.3)3/21 (14.3)243/1587 (15.3)0/3 (0)
 Computed tomography1111/1562 (71.1)19/28 (67.9)1113/1572 (70.8)17/18 (94.4)1116/1569 (71.1)14/21 (66.7)1127/1587 (71)3/3 (100)
Hubei
 Yes638/1562 (40.8)9/28 (32.1)635/1572 (40.4)12/18 (66.7)631/1569 (40.2)16/21 (76.2)645/1587 (40.6)2/3 (66.7)
 No924/1562 (59.2)19/28 (67.9)937/1572 (59.6)6/18 (33.3)938/1569 (59.8)5/21 (23.8)942/1587 (59.4)1/3 (33.3)
Wuhan-contacted
 Yes1312/1562 (84)22/28 (78.6)1316/1572 (83.7)18/18 (100)1316/1569 (83.9)18/21 (85.7)1331/1587 (83.9)3/3 (100)
 No250/1562 (16)6/28 (21.4)256/1572 (16.3)0/18 (0)253/1569 (16.1)3/21 (14.3)256/1587 (16.1)0/3 (0)
Severity245/1562 (15.7)9/28 (32.1)245/1572 (15.6)9/18 (50)246/1569 (15.7)8/21 (38.1)253/1587 (15.9)1/3 (33.3)
Composite endpoint128/1562 (8.2)3/28 (10.7)124/1572 (7.9)7/18 (38.9)125/1569 (8)6/21 (28.6)130/1587 (8.2)1/3 (33.3)
Deaths49/1562 (3.1)1/28 (3.6)47/1572 (3.0)3/18 (16.7)45/1569 (2.9)5/21 (23.8)50/1587 (3.2)0/3 (0)
Admission to ICU98/1562 (6.3)1/28 (3.6)94/1572 (6.0)5/18 (27.8)98/1569 (6.2)1/21 (4.8)98/1587 (6.2)1/3 (33.3)
Invasive ventilation48/1562 (3.1)2/28 (7.1)48/1562 (3.1)2/18 (11.1)49/1569 (3.1)1/21 (4.8)50/1587 (3.2)0/3 (0)

Data are mean±standard deviation, n/N (%), where N is the total number of patients with available data.

COPD: chronic obstructive pulmonary disease; ICU: intensive care unit.