Predictors of latent tuberculosis infection (LTBI) treatment completion and Régie de l'assurance maladie du Québec (RAMQ)-paid costs for health service use during LTBI treatment period (n=10 559)
| Patient and physician characteristics | LTBI treatment completion# | Mean RAMQ-paid costs¶ | ||||
| n (%) completing | Univariable RR (95% CI) | Multivariable RR (95% CI) + | Mean±sd costs CAD | Univariable cost ratio (95% CI) | Multivariable cost ratio (95% CI) + | |
| Starting LTBI regimen | ||||||
| Rifampin | 468 (53.5) | 1.4 (1.2–1.7) | 1.5 (1.3–1.7) | 3048±10 505 | 1.1 (0.7, 1.8) | 0.7 (0.5, 0.9) |
| Isoniazid | 3570 (36.9) | 1.0 | 1.0 | 2694±13 539 | 1.0 | 1.0 |
| Sex | ||||||
| Male | 1859 (40.6) | 1.1 (1.1–1.2) | 1.1 (1.0–1.1) | 3574±16 989 | 1.7 (1.4, 2.1) | 1.2 (0.9, 1.4) |
| Female | 2179 (36.4) | 1.0 | 1.0 | 2073±9547 | 1.0 | 1.0 |
| Age group years | ||||||
| 0–19 | 975 (41.3) | 1.2 (1.1–1.3) | 1.2 (1.1–1.3) | 883±6707 | 0.8 (0.5, 1.2) | 0.96 (0.7, 1.3) |
| 20–34 | 1162 (35.1) | 1.0 | 1.0 | 1091±8765 | 1.0 | 1.0 |
| 35–64 | 1629 (39.2) | 1.2 (1.1–1.3) | 1.2 (1.1–1.3) | 3297±14 188 | 3.1 (2.2, 4.2) | 2.3 (1.7, 3.1) |
| ≥65 | 272 (37.3) | 1.2 (1.1–1.4) | 1.2 (1.0–1.4) | 12 832±28 269 | 11.7 (8.5, 16.1) | 6.3 (4.3, 9.2) |
| Any hospitalisation in year before index | ||||||
| Yes | 316 (28.2) | 0.7 (0.7–0.8) | 0.7 (0.6–0.8) | 11 621±31 892 | 6.9 (5.7, 8.5) | 2.8 (2.2, 3.7) |
| No | 3722 (39.4) | 1.0 | 1.0 | 1668±8198 | 1.0 | 1.0 |
| Any Charlson co-morbidities | ||||||
| Yes | 100 (26.0) | 0.7 (0.6–0.9) | 0.8 (0.6, 0.9) | 20 641±43 686 | 10.1 (7.8,13.0) | - |
| No | 3938 (38.7) | 1.0 | 1.0 | 2046±99 806 | 1.0 | |
| HIV/AIDS | ||||||
| Yes | 55 (50.9) | 1.5 (1.2–1.8) | 1.5 (1.3–1.9) | 17 334±46 256 | 6.7 (3.9,1 1.7) | 5.5 (3.6, 8.6) |
| No | 3983 (38.1) | 1.0 | 1.0 | 2573±12 448 | 1.0 | 1.0 |
| Cancer | ||||||
| Yes | 106 (30.2) | 0.9 (0.7–1.0) | 19 245±43 269 | 8.9 (6.7,11.8) | 3.1 (2.1, 4.6) | |
| No | 3932 (38.5) | 1.0 | 2156±10 462 | 1.0 | 1.0 | |
| Diabetes | ||||||
| Yes | 172 (37.7) | 1.0 (0.9–1.2) | 12 220±33 187 | 5.3 (4.0,7.0) | 1.6 (1.2, 2.0) | |
| No | 3866 (38.3) | 1.0 | 2295±11 464 | 1.0 | 1.0 | |
| Renal failure | ||||||
| Yes | 108 (38.6) | 1.1 (0.9–1.4) | 1.2 (0.96, 1.4) | 18 853±30 224 | 8.2 (6.3,10.6) | 3.8 (2.9, 4.9) |
| No | 3930 (38.2) | 1.0 | 1.0 | 2285±12 248 | 1.0 | 1.0 |
| Solid organ transplant | ||||||
| Yes | 18 (43.9) | 1.2 (0.9–1.7) | 22 594±69 369 | 8.5 (3.3,21.8) | - | |
| No | 4020 (38.2) | 1.0 | 2646±12 575 | 1.0 | ||
| Silicosis | ||||||
| Yes | 11 (45.8) | 1.3 (0.8–2.2) | 5951±12 657 | 2.2 (0.9,5.5) | - | |
| No | 4027 (38.2) | 1.0 | 2716±13 316 | 1.0 | ||
| Tumour necrosis factor-α inhibitors | ||||||
| Yes | 12 (37.5) | 1.1 (0.7–1.7) | 13 866±7921 | 5.2 (3.9,6.8) | 5.3 (3.7, 7.8) | |
| No | 4026 (38.2) | 1.0 | 2690±13 313 | 1.0 | 1.0 | |
| Any psychiatric diagnosis | ||||||
| Yes | 305 (33.9) | 0.9 (0.8–1.0) | 7949±24 198 | 3.6 (2.8,4.6) | 2.5 (1.8, 3.5) | |
| No | 3733 (38.7) | 1.0 | 2237±11 682 | 1.0 | 1.0 | |
| Physician licensing | ||||||
| Other specialist | 1361 (42.2) | 1.1 (1.0–1.2) | 1.1 (0.98, 1.2) | 2714±13 104 | 0.98 (0.7,1.4) | 1.3 (1.0, 1.7) |
| Family physician | 712 (32.5) | 1.0 | 1.0 | 2765±14 239 | 1.0 | 1.0 |
| Year of treatment start | ||||||
| 2007 | 782 (38.5) | 1.1 (0.96–1.2) | 1.1 (0.99–1.2) | 2559±14 225 | 1.0 (0.8,1.5) | - |
| 2006 | 775 (38.8) | 1.1 (0.99–1.2) | 1.1 (0.99–1.2) | 3031±11 741 | 1.2 (0.8,1.6) | |
| 2005 | 873 (40.5) | 1.2 (1.1–1.3) | 1.1 (1.0–1.3) | 2832±14 448 | 1.1 (0.9,1.7) | |
| 2004 | 814 (37.9) | 1.1 (0.96–1.2) | 1.1 (0.97–1.2) | 2712±12 230 | 1.1 (0.7,1.4) | |
| 2003 | 794 (35.7) | 1.0 | 1.0 | 2505±13 649 | 1.0 | |
Missing: treating physician (n=78). #: Treatment completion for 9H was 270 doses dispensed in 12 months and for 4R was 120 doses dispensed in 6 months. ¶: costs during LTBI treatment period (from first date with a TB drug dispensed to 30 days after the last TB drug dispensed), limited to a period of up to 1 year for H and 6 months for R. Costs reported in 2011 Canadian dollars (CAD). RAMQ-paid costs are sum of hospitalisations, emergency department visits, hospital day procedures,physician billingand drugs dispensed (TB and non-TB drugs). +: Adjusted models including all variables with p<0.2 in multivariable models.