Airflow limitation (GOLD stage III or IV) | Dyspnoea grade (mMRC score ≥2) | Exercise capacity (6MWD <350 m) | BODE index (BODE score >4) | Exacerbations (≥1 severe exacerbation) | Hypoxaemia (PaO2 <55 mmHg) | Hypercapnia (PaCO2 ≥50 mmHg) | |
Adjusted OR# (95% CI) for log hs-TnI ng·L−1 | 1.15 (1.03–1.29) | 1.29 (1.14–1.45) | 1.20 (1.05–1.38) | 1.19 (1.01–1.39) | 1.20 (1.05–1.38) | 1.19 (1.03–1.38) | 1.56 (1.10–2.20) |
p-value | 0.016 | <0.001 | 0.010 | 0.040 | 0.007 | 0.022 | 0.012 |
GOLD: Global Initiative for Chronic Obstructive Lung Disease; mMRC: modified Medical Research Council; 6MWD: 6-min walk distance; BODE: body mass index, airway obstruction, dyspnoea and exercise capacity; PaO2: arterial oxygen tension; PaCO2: arterial carbon dioxide tension. #: odds ratios and corresponding p-values for log-transformed hs-TnI as predictor for different COPD assessments calculated by separate logistic regression analyses are given. Each column represents a separate analysis with the dependent variable stated in brackets. All analyses were adjusted for age, sex, smoking status, hypertension, hyperlipidaemia, coronary artery disease and history of myocardial infarction.