Multivariate logistic regression analysis of the presence of thoracic aorta calcification (TAC) and coronary artery calcification (CAC) for moderation effect of obstructive sleep apnoea (OSA) severity and epicardial fat volume (EFV)
| No OSA (AHI <5 events·h−1) | Mild OSA (AHI 5– <15 events·h−1) | Moderate-to-severe OSA (AHI ≥15 events·h−1) | ||||
| OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Subjects | 1096 (50.81) | 700 (32.45) | 361 (16.74) | |||
| aTAC (≥100 units) | ||||||
| Lower EFV tertile (T1) | Reference | 1.04 (0.72–1.51) | 0.83 | 1.14 (0.76–1.72) | 0.54 | |
| Middle EFV tertile (T2) | 0.87 (0.55–1.35) | 0.53 | 1.35 (0.89–2.04) | 0.16 | 1.46 (0.96–2.23) | 0.08 |
| Upper EFV tertile (T3) | 1.01 (0.54–1.92) | 0.97 | 1.86 (1.14–3.05) | 0.01 | 2.11 (1.30–3.43) | 0.003 |
| dTAC (≥100 units) | ||||||
| Lower EFV tertile (T1) | Reference | 0.75 (0.52–1.08) | 0.12 | 1.08 (0.73–1.62) | 0.70 | |
| Middle EFV tertile (T2) | 0.98 (0.64–1.50) | 0.93 | 1.59 (1.06–2.37) | 0.02 | 1.22 (0.80–1.85) | 0.36 |
| Upper EFV tertile (T3) | 1.37 (0.73–2.58) | 0.33 | 1.51 (0.92–2.49) | 0.11 | 1.38 (0.84–2.26) | 0.21 |
| TAC (≥400 units) | ||||||
| Lower EFV tertile (T1) | Reference | 0.63 (0.42–0.94) | 0.02 | 0.89 (0.58–1.38) | 0.60 | |
| Middle EFV tertile (T2) | 0.76 (0.48–1.22) | 0.43 | 1.19 (0.77–1.83) | 0.43 | 1.13 (0.73–1.75) | 0.60 |
| Upper EFV tertile (T3) | 0.99 (0.51–1.92) | 0.97 | 1.41 (0.84–2.36) | 0.20 | 1.29 (0.77–2.14) | 0.33 |
| CAC (>0 units) | ||||||
| Lower EFV tertile (T1) | Reference | 1.27 (0.87–1.84) | 0.21 | 1.35 (0.89–2.04) | 0.16 | |
| Middle EFV tertile (T2) | 0.83 (0.52–1.31) | 0.42 | 0.98 (0.63–1.53) | 0.94 | 1.19 (0.77–1.83) | 0.43 |
| Upper EFV tertile (T3) | 1.62 (0.88–2.98) | 0.12 | 1.17 (0.71–1.95) | 0.54 | 1.29 (0.79–2.10) | 0.32 |
Data for numbers of subjects are presented as n (%). AHI: apnoea–hypopnoea index; aTAC: ascending TAC; dTAC: descending TAC. The logistic regression analysis was adjusted for age, sex, body mass index, hypertension, type 2 diabetes, high-density lipoprotein cholesterol, how-density lipoprotein cholesterol and pack-years of smoking.